Safety of Lactobacillus plantarum ST8Sh and Its Bacteriocin

dc.contributor.authorTodorov, Svetoslav Dimitrov
dc.contributor.authorPerin, Luana M.
dc.contributor.authorCarneiro, Bruno M. [UNESP]
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.authorHolzapfel, Wilhelm
dc.contributor.authorNero, Luís Augusto
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso
dc.contributor.institutionHandong Global University
dc.date.accessioned2018-12-11T17:10:05Z
dc.date.available2018-12-11T17:10:05Z
dc.date.issued2017-09-01
dc.description.abstractTotal DNA extracted from Lb. plantarum ST8Sh was screened for the presence of more than 50 genes related to production of biogenic amines (histidine decarboxylase, tyrosine decarboxylase, and ornithine decarboxylase), virulence factors (sex pheromones, gelatinase, cytolysin, hyaluronidase, aggregation substance, enterococcal surface protein, endocarditis antigen, adhesion of collagen, integration factors), and antibiotic resistance (vancomycin, tetracycline, erythromycin, gentamicin, chloramphenicol, bacitracin). Lb. plantarum ST8Sh showed a low presence of virulence genes. Only 13 genes were detected (related to sex pheromones, aggregation substance, adhesion of collagen, tetracycline, gentamicin, chloramphenicol, erythromycin, but not to vancomycin, and bacitracin) and may be considered as indication of safety for application in fermented food products. In addition, interaction between Lb. plantarum ST8Sh and drugs from different groups were determined in order to establish possible application of the strain in combination with commercial drugs. Cytotoxicity of the semi-purified bacteriocins produced by Lb. plantarum ST8Sh was depended on applied concentration—highly cytotoxic when applied at 25 μg/mL and no cytotoxicity at 5 μg/mL.en
dc.description.affiliationVeterinary Department Universidade Federal de Viçosa, Campus UFV
dc.description.affiliationDepartamento de Engenharia e Tecnologia de Alimentos UNESP - Universidade Estadual Paulista Instituto de Biociências Letras e Ciências Exatas
dc.description.affiliationInstituto de Ciências Exatas e Naturais Universidade Federal de Mato Grosso
dc.description.affiliationGEE Handong Global University
dc.description.affiliationUnespDepartamento de Engenharia e Tecnologia de Alimentos UNESP - Universidade Estadual Paulista Instituto de Biociências Letras e Ciências Exatas
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.format.extent334-344
dc.identifierhttp://dx.doi.org/10.1007/s12602-017-9260-3
dc.identifier.citationProbiotics and Antimicrobial Proteins, v. 9, n. 3, p. 334-344, 2017.
dc.identifier.doi10.1007/s12602-017-9260-3
dc.identifier.file2-s2.0-85013658757.pdf
dc.identifier.issn1867-1306
dc.identifier.lattes7991082362671212
dc.identifier.orcid0000-0001-5693-6148
dc.identifier.scopus2-s2.0-85013658757
dc.identifier.urihttp://hdl.handle.net/11449/174264
dc.language.isoeng
dc.relation.ispartofProbiotics and Antimicrobial Proteins
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBacteriocins
dc.subjectCytotoxicity
dc.subjectLactobacillus plantarum
dc.subjectProbiotics
dc.subjectSafety
dc.subjectVirulence
dc.titleSafety of Lactobacillus plantarum ST8Sh and Its Bacteriocinen
dc.typeArtigo
unesp.author.lattes7991082362671212[4]
unesp.author.orcid0000-0001-5693-6148[4]

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