Fatores preditivos do sucesso da inseminação intrauterina: A morfologia espermática de acordo com o novo manual de laboratório da Organização Mundial de Saúde

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dc.contributor.authorLopes, Fabio Biaggioni
dc.contributor.authorSetti, Amanda Souza
dc.contributor.authorBraga, Daniela Paes de Almeida Ferreira
dc.contributor.authorFigueira, Rita de Cássia Savio
dc.contributor.authorIaconelli Jr., Assumpto
dc.contributor.authorBorges Jr., Edson [UNESP]
dc.contributor.institutionFertility - Centro de Fertilização Assistida
dc.contributor.institutionInstituto Sapientiae - Centro de Ensino e Pesquisa em Reprodução Assistida
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:24:43Z
dc.date.available2014-05-27T11:24:43Z
dc.date.issued2010-07-01
dc.description.abstractObjective: The aim of our study was to assess the likelihood of IUI success as a function of the previously described predictive factors, including sperm morphology according to the new reference values defined by WHO. Material and Methods: This retrospective study enrolled 300 couples which underwent IUI. Regression analyses were used to correlate maternal age, number of preovulatory follicles on the day of hCG administration, number of inseminated motile sperm, and normal sperm morphology with clinical pregnancy. Results are expressed as odds ratio (OR) with 95% of confidence intervals (CI). Results: Women older than 35 years showed a lower pregnancy rate (6.5% vs 18.2%, p=0.017). Logistic regression models confirmed the lower chance of pregnancy occurrence for older women (OR: 0.39; CI: 0.16-0.96; p=0.040). The presence of two or more preovulatory follicles on the day of hCG administration resulted in higher pregnancy rate when compared to cases in which only one preovulatory follicle was present (18.6% vs 8.2%, p=0.011). The regression model showed a more than two fold increase on probability of pregnancy when two or more preovulatory follicles were detected (OR: 2.58; CI: 1.22-5.46, p=0.013). The number of inseminated motile sperm positively influenced pregnancy occurrence (OR: 1.47; CI: 0.88-3.14, p=0.027). Similar pregnancy rates were observed when semen samples were classified as having normal or abnormal morphology (10.6% vs 10.2%, p=0.936). Conclusion: Our results demonstrate that sperm morphological normalcy, according to the new reference value, has no predictive value on IUI outcomes. © Todos os direitos reservados a SBRA - Sociedade Brasileira de Reprodução Assistida.en
dc.description.affiliationFertility - Centro de Fertilização Assistida, Av. Brigadeiro Luis Antonio, 4545, São Paulo - SP, CEP: 01401-002
dc.description.affiliationInstituto Sapientiae - Centro de Ensino e Pesquisa em Reprodução Assistida, Rua Vieira Maciel, 62, São Paulo - SP, CEP: 04503-040
dc.description.affiliationDepartmento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu UNESP, Botucatu - SP
dc.description.affiliationUnespDepartmento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu UNESP, Botucatu - SP
dc.format.extent28-31
dc.identifierhttp://www.jbra.com.br/archive/JBRA_3_2010.pdf
dc.identifier.citationJornal Brasileiro de Reproducao Assistida, v. 14, n. 3, p. 28-31, 2010.
dc.identifier.issn1517-5693
dc.identifier.issn1518-0557
dc.identifier.scopus2-s2.0-79954433863
dc.identifier.urihttp://hdl.handle.net/11449/71769
dc.language.isopor
dc.relation.ispartofJornal Brasileiro de Reproducao Assistida
dc.relation.ispartofsjr0,282
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectIntrauterine insemination
dc.subjectPregnancy rate
dc.subjectSperm morphology
dc.subjectrecombinant chorionic gonadotropin
dc.subjectrecombinant follitropin
dc.subjectadult
dc.subjectbody mass
dc.subjectcell structure
dc.subjectcontrolled study
dc.subjectendometrium
dc.subjectfemale
dc.subjectfemale infertility
dc.subjectgestational age
dc.subjecthuman
dc.subjecthuman cell
dc.subjectintrauterine insemination
dc.subjectluteal phase
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmale infertility
dc.subjectmaternal age
dc.subjectovary follicle development
dc.subjectovulation induction
dc.subjectpaternal age
dc.subjectprediction
dc.subjectpredictive value
dc.subjectpregnancy
dc.subjectpregnancy outcome
dc.subjectpregnancy rate
dc.subjectprobability
dc.subjectreference value
dc.subjectretrospective study
dc.subjectsampling
dc.subjectsemen analysis
dc.subjectspermatozoon
dc.subjectspermatozoon count
dc.subjectspermatozoon motility
dc.subjecttransvaginal echography
dc.subjecttreatment outcome
dc.subjectworld health organization
dc.titleFatores preditivos do sucesso da inseminação intrauterina: A morfologia espermática de acordo com o novo manual de laboratório da Organização Mundial de Saúdept
dc.title.alternativePredictive factors of intrauterine insemination success: Sperm morphology according to the new World Health Organization laboratory manualen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentGinecologia e Obstetrícia - FMBpt

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Botucatu - FMB - Faculdade de Medicina