The influence of physical activity in the progression of experimental lung cancer in mice

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dc.contributor.authorPaceli, Renato Batista
dc.contributor.authorCal, Rodrigo Nunes
dc.contributor.authorFerreira dos Santos, Carlos Henrique
dc.contributor.authorCordeiro, Jose Antonio
dc.contributor.authorNeiva, Cassiano Merussi [UNESP]
dc.contributor.authorNagamine, Kazuo Kawano [UNESP]
dc.contributor.authorCury, Patricia Maluf
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:26:08Z
dc.date.available2014-05-20T13:26:08Z
dc.date.issued2012-01-01
dc.description.abstractLung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors.The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer.Lung tumors were induced with a dose of 3 mg of urethane/kg, in 67 male Balb - C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed.The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p = 0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p = 0.03) but not in relation to group 2. There were no metastases or other changes in other organs.The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors. (c) 2012 Elsevier GmbH. All rights reserved.en
dc.description.affiliationSch Med Sao Jose do Rio Preto FAMERP, Dept Pathol & Forens Med, Sao Jose do Rio Preto, Brazil
dc.description.affiliationSch Med Sao Jose do Rio Preto FAMERP, Dept Epidemiol & Publ Hlth, Sao Jose do Rio Preto, Brazil
dc.description.affiliationSch Med Sao Jose do Rio Preto FAMERP, Phys Act & Hlth Lab, LAFIS, Sao Jose do Rio Preto, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Med Sao Jose do Rio Preto FAMERP, Sch Sci Bauru, UNESP, Sao Jose do Rio Preto, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Med Sao Jose do Rio Preto FAMERP, Sch Sci Bauru, UNESP, Sao Jose do Rio Preto, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent377-381
dc.identifierhttp://dx.doi.org/10.1016/j.prp.2012.04.006
dc.identifier.citationPathology Research and Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 208, n. 7, p. 377-381, 2012.
dc.identifier.doi10.1016/j.prp.2012.04.006
dc.identifier.issn0344-0338
dc.identifier.lattes4013645288037489
dc.identifier.urihttp://hdl.handle.net/11449/8376
dc.identifier.wosWOS:000307856500001
dc.language.isoeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relation.ispartofPathology Research and Practice
dc.relation.ispartofjcr1.466
dc.relation.ispartofsjr0,547
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPhysical activityen
dc.subjectExperimental lung canceren
dc.subjectAerobic exerciseen
dc.subjectAnaerobic exerciseen
dc.titleThe influence of physical activity in the progression of experimental lung cancer in miceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier Gmbh, Urban & Fischer Verlag
unesp.author.lattes4013645288037489[5]
unesp.author.orcid0000-0003-1635-3209[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentEducação Física - FCpt

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