EVALUATION OF CIRCUMSPOROZOITE PROTEIN OF Plasmodium vivax TO ESTIMATE ITS PREVALENCE IN OIAPOQUE, AMAPA STATE, BRAZIL, BORDERING FRENCH GUIANA

dc.contributor.authorMendonca Gomes, Margarete do Socorro
dc.contributor.authorFernandes Vieira, Jose Luiz
dc.contributor.authorCassiano, Gustavo Capatti [UNESP]
dc.contributor.authorMusset, Lise
dc.contributor.authorLegrand, Eric
dc.contributor.authorNacher, Mathieu
dc.contributor.authorCalvosa D'Almeida Couto, Vanja Suely
dc.contributor.authorDantas Machado, Ricardo Luiz [UNESP]
dc.contributor.authorRibeiro D'Almeida Couto, Alvaro Augusto
dc.contributor.institutionLab Cent Saude Publ Amapa
dc.contributor.institutionUniv Fed Para
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Pasteur
dc.contributor.institutionUniv Antilles Guyane
dc.contributor.institutionSecretaria Estado Saude Amapa
dc.contributor.institutionInst Evandro Chagas
dc.date.accessioned2018-11-26T15:43:44Z
dc.date.available2018-11-26T15:43:44Z
dc.date.issued2016-01-01
dc.description.abstractMalaria is a major health problem for people who live on the border between Brazil and French Guiana. Here we discuss Plasmodium vivax distribution pattern in the town of Oiapoque, Amapa State using the circumsporozoite (CS) gene as a marker. Ninety-one peripheral blood samples from P. vivax patients have been studied. Of these, 64 individuals were from the municipality of Oiapoque (Amapa State, Brazil) and 27 patients from French Guiana (August to December 2011). DNA extraction was performed, and a fragment of the P. vivax CS gene was subsequently analyzed using PCR/RFLP. The VK210 genotype was the most common in both countries (48.36% in Brazil and 14.28% in French Guiana), followed by the P. vivax-like (1.10% in both Brazil and French Guiana) and VK247 (1.10% only in Brazil) in single infections. We were able to detect all three CS genotypes simultaneously in mixed infections. There were no statistically significant differences either regarding infection site or parasitaemia among individuals with different genotypes. These results suggest that the same genotypes circulating in French Guiana are found in the municipality of Oiapoque in Brazil. These findings suggest that there may be a dispersion of parasitic populations occurring between the two countries. Most likely, this distribution is associated with prolonged and/or more complex transmission patterns of these genotypes in Brazil, bordering French Guiana.en
dc.description.affiliationLab Cent Saude Publ Amapa, Amapa, Amapa State, Brazil
dc.description.affiliationUniv Fed Para, Belem, Para, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Paulo, Brazil
dc.description.affiliationInst Pasteur, Ctr Natl Ref Paludisme, Lab parasitol, Cayenne, French Guiana
dc.description.affiliationUniv Antilles Guyane, Cayenne, French Guiana
dc.description.affiliationSecretaria Estado Saude Amapa, Macapa, Brazil
dc.description.affiliationInst Evandro Chagas, Ananindeua, Para, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Paulo, Brazil
dc.description.sponsorshipNational Scientific and Technological Development in the Research Program for Health System Unique
dc.description.sponsorshipGovernment of the State of Amapa
dc.description.sponsorshipCentral Public Health Laboratory (LACEN) of Amapa
dc.description.sponsorshipIdNational Scientific and Technological Development in the Research Program for Health System Unique: 00077/2008/MCT/CNPq/SETEC
dc.description.sponsorshipIdNational Scientific and Technological Development in the Research Program for Health System Unique: 35.000.162/2009
dc.format.extent4
dc.identifierhttp://dx.doi.org/10.1590/S1678-9946201658072
dc.identifier.citationRevista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo: Inst Medicina Tropical Sao Paulo, v. 58, 4 p., 2016.
dc.identifier.doi10.1590/S1678-9946201658072
dc.identifier.fileS0036-46652016005000504.pdf
dc.identifier.issn0036-4665
dc.identifier.scieloS0036-46652016005000504
dc.identifier.urihttp://hdl.handle.net/11449/159427
dc.identifier.wosWOS:000396241000023
dc.language.isoeng
dc.publisherInst Medicina Tropical Sao Paulo
dc.relation.ispartofRevista Do Instituto De Medicina Tropical De Sao Paulo
dc.relation.ispartofsjr0,669
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPlasmodium vivax
dc.subjectCircumsporozoite protein
dc.subjectBrazil-French Guiana border
dc.subjectGenetic marker
dc.titleEVALUATION OF CIRCUMSPOROZOITE PROTEIN OF Plasmodium vivax TO ESTIMATE ITS PREVALENCE IN OIAPOQUE, AMAPA STATE, BRAZIL, BORDERING FRENCH GUIANAen
dc.typeArtigo
dcterms.rightsHolderInst Medicina Tropical Sao Paulo
unesp.author.orcid0000-0003-4725-0712[5]
unesp.author.orcid0000-0002-8955-3204[8]

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