Cardiac function in dogs with chronic Chagas cardiomyopathy undergoing autologous stem cell transplantation into the coronary arteries

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dc.contributor.authorSousa, Marlos G.
dc.contributor.authorPaulino-Junior, Daniel [UNESP]
dc.contributor.authorPascon, Joao P. E. [UNESP]
dc.contributor.authorPereira-Neto, Glaucia B. [UNESP]
dc.contributor.authorCarareto, Roberta
dc.contributor.authorChampion, Tatiana [UNESP]
dc.contributor.authorCamacho, Aparecido Antonio [UNESP]
dc.contributor.institutionUniversidade Federal do Tocantins (UFT)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:14:16Z
dc.date.available2014-05-20T13:14:16Z
dc.date.issued2011-08-01
dc.description.abstractThis study assessed the effects of a single intracoronary injection of autologous stem cells on the cardiac function of dogs with Chagas cardiomyopathy. Bone-marrow-derived stem cells were delivered into the right and left coronary arteries of 5 mature dogs with mildly compromised cardiac function due to chronic Chagas cardiomyopathy. Blood pressure and electrocardiographic and echocardiographic parameters were recorded at monthly intervals for 6 mo in the 3 dogs that survived. Although no changes were observed in the electrocardiogram and blood pressure, there was a significant increase in peak velocity of aortic flow 3 mo after stem cell transplantation. Pre-ejection period, isovolumic relaxation time, and the Tei index of myocardial performance were reduced significantly 4 mo after the procedure. All significant changes persisted to the end of the study. The results suggest that the transplantation of autologous bone-marrow-derived stem cells into the coronary arteries of dogs with Chagas cardiomyopathy may have a beneficial effect but the small number of dogs studied was a limitation.en
dc.description.affiliationFed Univ Tocantins State UFT, Coll Vet Med & Anim Sci, Araguaina, Tocantins, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Coll Agr & Veterinarian Sci FCAV, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Coll Agr & Veterinarian Sci FCAV, São Paulo, Brazil
dc.format.extent869-874
dc.identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135031/#
dc.identifier.citationCanadian Veterinary Journal-revue Veterinaire Canadienne. Ottawa: Canadian Vet Med Assoc, v. 52, n. 8, p. 869-874, 2011.
dc.identifier.issn0008-5286
dc.identifier.lattes9642688764978907
dc.identifier.urihttp://hdl.handle.net/11449/1793
dc.identifier.wosWOS:000293990600005
dc.language.isoeng
dc.publisherCanadian Vet Med Assoc
dc.relation.ispartofCanadian Veterinary Journal-revue Veterinaire Canadienne
dc.relation.ispartofjcr0.558
dc.relation.ispartofsjr0,321
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleCardiac function in dogs with chronic Chagas cardiomyopathy undergoing autologous stem cell transplantation into the coronary arteriesen
dc.typeArtigo
dcterms.licensehttp://www.ncbi.nlm.nih.gov/pmc/about/copyright/
dcterms.rightsHolderCanadian Vet Med Assoc
unesp.author.lattes9642688764978907[7]
unesp.author.orcid0000-0003-1367-9828[1]
unesp.author.orcid0000-0002-7346-1620[6]
unesp.author.orcid0000-0001-9802-9271[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.departmentClínica e Cirurgia Veterinária - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias