Lobe identity in the Mongolian gerbil prostatic complex: A new rodent model for prostate study

dc.contributor.authorRochel, Sabrina Santos
dc.contributor.authorBruni-Cardoso, Alexandre
dc.contributor.authorTaboga, Sebastiao Roberto
dc.contributor.authorLeite Vilamaior, Patricia Simone
dc.contributor.authorGoes, Rejane Maira
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:01:35Z
dc.date.available2014-05-20T14:01:35Z
dc.date.issued2007-10-01
dc.description.abstractKnowledge of structural and physiological differences among the prostatic lobes (PL) is the basis for development of experimental studies in traditional laboratory rodents. Although Mongolian gerbil reproductive organs have been increasingly investigated, its prostate structure is far from being properly known, and investigations of this organ focused on the ventral lobe (VL). Thus, the present study provides a thorough morphological description of prostatic complex in the male adult gerbil on the basis of topographic, histological, and ultrastructural analysis and ductal branching. Like other rodents, four pairs of PL were observed. However, in contrast to the rat and mouse, the VL is the least voluminous component and the dorsolateral lobe (DLL) is the most prominent and spatially isolated from remaining PL. The occurrence of a dorsal lobe (DL), hidden between bladder and insertion of seminal vesicles, has not been mentioned in previous reports with Mongolian gerbil. Collagenase digestion followed by microdissection revealed that, except for DL, which has a tubularacinar organization, all PL exhibit tubular organization and variable ductal branching. Distinct histological and ultrastructural features such as secretory epithelium, aspect of luminal secretion and stromal organization are reported for each PL and are confirmed by morphometric and stereological methods. Histological sections showed at least three intralobar segments in VL and DL. Ultrastructural analysis evidenced that, although luminal epithelial cells of PL share typical features of exocrine secretory cells, there are striking lobe phenotypical variations. Both merocrine and apocrine pathways are observed in variable rates in all PL, with the predominance of the former in the DLL and the latter in the CG. The morphological observations presented herein point to distinct structural identities for each PL, which probably reflects,specific functional compromise of seminal fluid secretion. These data also point to the gerbil as a good model for investigations concerning the regulation of prostate development and homeostasis, mainly with regard to the dorsal and dorsolateral PL.en
dc.description.affiliationSão Paulo State Univ, Inst Biosci Humanities & Exact Sci, IBILCE UNESP, Dept Biol & Anim Biol,Grad Program, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Inst Biosci Humanities & Exact Sci, IBILCE UNESP, Dept Biol & Anim Biol,Grad Program, Sao Jose do Rio Preto, SP, Brazil
dc.format.extent1233-1247
dc.identifierhttp://dx.doi.org/10.1002/ar.20585
dc.identifier.citationAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Hoboken: Wiley-liss, v. 290, n. 10, p. 1233-1247, 2007.
dc.identifier.doi10.1002/ar.20585
dc.identifier.fileWOS000249568100005.pdf
dc.identifier.issn1932-8486
dc.identifier.lattes1445259468526188
dc.identifier.lattes0947193347312157
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0002-3622-460X
dc.identifier.urihttp://hdl.handle.net/11449/21730
dc.identifier.wosWOS:000249568100005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology
dc.relation.ispartofjcr1.373
dc.relation.ispartofsjr0,766
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectprostate lobespt
dc.subjectgerbilpt
dc.subjectductal branchingpt
dc.subjectintralobarpt
dc.subjectvariationspt
dc.subjectultrastructurept
dc.titleLobe identity in the Mongolian gerbil prostatic complex: A new rodent model for prostate studyen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes1445259468526188
unesp.author.lattes0947193347312157[5]
unesp.author.orcid0000-0001-9559-5497[4]
unesp.author.orcid0000-0002-0970-4288[3]
unesp.author.orcid0000-0002-3622-460X[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBILCEpt

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