Regulatory T cells in dogs with multicentric lymphoma: peripheral blood quantification at diagnosis and after initial stage chemotherapy

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dc.contributor.authorMunhoz, T. D.
dc.contributor.authorAnai, L. A. [UNESP]
dc.contributor.authorFonseca, D. M.
dc.contributor.authorSemolin, L. M. [UNESP]
dc.contributor.authorSueiro, F. R.
dc.contributor.authorTinucci-Costa, M. [UNESP]
dc.contributor.institutionCtr Univ Barao Maua
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionVetPat
dc.date.accessioned2018-11-26T15:28:39Z
dc.date.available2018-11-26T15:28:39Z
dc.date.issued2016-01-01
dc.description.abstractLymphoma is the most common hematopoietic malignancy in dogs and one of the most frequent among all neoplastic diseases in this species. It can occur in several anatomical locations with distinct histological and immunophenotypes. Depending on the host immune response towards the tumor, prognosis information could be collected. Because its well established immunosuppressant, antitumor activity, the function of regulatory T cells (Tregs) in canine neoplasias has been investigated. In this study, we sought to quantify, using flow cytometry, the Tregs subpopulation in peripheral blood of healthy dogs (10) and in those diagnosed with type-B (14) and type-T (8) multicentric lymphoma before (at diagnosis) and after the first cycle (5-week) of 19-week Madison-Wisconsin (MW) protocol of chemotherapy. Our results indicated that dogs with lymphoma showed higher percentage of Tregs (18,84+/-2,56) when compared to healthy dogs (4,70+/-0,50) (P<0,01). In addition, 5-week chemotherapy treatment reduced the Tregs subpopulation (7,54+/-1,08) to levels similar to control (4,70+/-0,50) (P>0,05). There was no difference in Tregs percentage between B-type (17,45+/-2,77) and T-type (21,27+/-5,27) lymphoma (P> 0,05). With this, we conclude that canine lymphoma increases Tregs in the peripheral blood and the MW protocol of chemotherapy reduces this cell subpopulation to control values.en
dc.description.affiliationCtr Univ Barao Maua, Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Jaboticabal, SP, Brazil
dc.description.affiliationUniv Sao Paulo, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationVetPat, Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2010/11908-5
dc.format.extent1-9
dc.identifierhttp://dx.doi.org/10.1590/1678-4162-8237
dc.identifier.citationArquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 68, n. 1, p. 1-9, 2016.
dc.identifier.doi10.1590/1678-4162-8237
dc.identifier.fileS0102-09352016000100001.pdf
dc.identifier.issn0102-0935
dc.identifier.scieloS0102-09352016000100001
dc.identifier.urihttp://hdl.handle.net/11449/158687
dc.identifier.wosWOS:000369237800001
dc.language.isoeng
dc.publisherArquivo Brasileiro Medicina Veterinaria Zootecnia
dc.relation.ispartofArquivo Brasileiro De Medicina Veterinaria E Zootecnia
dc.relation.ispartofsjr0,248
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectdogs
dc.subjectmulticentric lymphoma
dc.subjectflow cytometry
dc.subjectregulatory T cells
dc.titleRegulatory T cells in dogs with multicentric lymphoma: peripheral blood quantification at diagnosis and after initial stage chemotherapyen
dc.typeArtigo
dcterms.rightsHolderArquivo Brasileiro Medicina Veterinaria Zootecnia

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