Loss of the Ability to Control Right-to-Left Shunt Does Not Influence the Metabolic Responses to Temperature Change or Long-Term Fasting in the South American Rattlesnake Crotalus durissus

dc.contributor.authorLeite, Cleo A. C.
dc.contributor.authorWang, Tobias
dc.contributor.authorTaylor, Edwin W. [UNESP]
dc.contributor.authorAbe, Augusto S. [UNESP]
dc.contributor.authorLeite, Gabrielle S. P. C.
dc.contributor.authorAndrade, Denis O. V. de [UNESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionNatl Inst Sci & Technol Comparat Physiol
dc.contributor.institutionAarhus Univ
dc.contributor.institutionUniv Birmingham
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:04Z
dc.date.available2014-12-03T13:11:04Z
dc.date.issued2014-07-01
dc.description.abstractIn the undivided ventricle of noncrocodilian reptiles, the blood perfusing the systemic circulation is a controlled combination of oxygenated pulmonary blood, flowing from left to right across the heart, and relatively deoxygenated systemic blood, flowing from right to left. A clear inverse correlation has been experimentally established between metabolic demand and the magnitude of right-to-left cardiac shunt in several reptile groups. Unilateral left vagotomy renders the single effective pulmonary artery of the South American rattlesnake (Crotalus durissus) unable to adjust the magnitude of blood flow to the lung. This provides a unique model for investigation of the long-term consequences of abolition of the cardiac shunt in a squamate reptile. Rattlesnakes-vagotomized on the left or right side or sham operated-were exposed to long-term food deprivation or temperature change. Loss of control of the cardiac shunt following selective vagotomy did not change the progressive decrease in body mass or the onset of identifiable fasting stages. Resting metabolic rate and the increase in oxygen uptake measured during spontaneous or forced activity were also unchanged. The responses to reductions in temperature (from 30 degrees to 20 degrees or 15 degrees C) in adult snakes or juvenile snakes were similarly unaffected by vagal transection. These data support rejection of the hypothesis that adjustment of the cardiac shunt is central to the control metabolic rate in squamate reptiles.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biol, BR-09972270 Sao Paulo, Brazil
dc.description.affiliationNatl Inst Sci & Technol Comparat Physiol, Sao Paulo, Brazil
dc.description.affiliationAarhus Univ, Dept Biosci, DK-8000 Aarhus C, Denmark
dc.description.affiliationUniv Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
dc.description.affiliationUniv Estadual Paulista, Dept Zool, BR-13506900 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Zool, BR-13506900 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipDanish Research Council
dc.format.extent568-575
dc.identifierhttp://dx.doi.org/10.1086/675863
dc.identifier.citationPhysiological And Biochemical Zoology. Chicago: Univ Chicago Press, v. 87, n. 4, p. 568-575, 2014.
dc.identifier.doi10.1086/675863
dc.identifier.fileWOS000337738400008.pdf
dc.identifier.issn1522-2152
dc.identifier.urihttp://hdl.handle.net/11449/112814
dc.identifier.wosWOS:000337738400008
dc.language.isoeng
dc.publisherUniv Chicago Press
dc.relation.ispartofPhysiological and Biochemical Zoology
dc.relation.ispartofjcr2.291
dc.relation.ispartofsjr0,904
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleLoss of the Ability to Control Right-to-Left Shunt Does Not Influence the Metabolic Responses to Temperature Change or Long-Term Fasting in the South American Rattlesnake Crotalus durissusen
dc.typeArtigo
dcterms.rightsHolderUniv Chicago Press
unesp.author.lattes8776757457144680[4]
unesp.author.orcid0000-0002-6765-8726[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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