Luteal vascularity and embryo dynamics in mares during early gestation: Effect of age and endometrial degeneration

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dc.contributor.authorCamargo Ferreira, Jair [UNESP]
dc.contributor.authorLinhares Boakari, Yatta [UNESP]
dc.contributor.authorSousa Rocha, Noeme [UNESP]
dc.contributor.authorSaules Ignácio, Fernanda [UNESP]
dc.contributor.authorBarbosa da Costa, Guilherme
dc.contributor.authorde Meira, Cezinande [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Franca
dc.date.accessioned2019-10-06T16:12:56Z
dc.date.available2019-10-06T16:12:56Z
dc.date.issued2019-03-01
dc.description.abstractThe present study characterized the luteal status and the dynamic of the conceptus during the first 20 days of gestation in mares with different ages and degrees of endometrial degeneration. Total area of the corpus luteum (CL), luteal vascularity, CL area with blood signals, progesterone concentrations (P4), embryonic vesicle diameter, number of embryonic location changes, embryonic fixation position and uterine contractility were evaluated. In Experiment 1, mares ≤6 years of age (Young group, 5.6 ± 0.2 years, n = 7 mares) and mares ≥15 years of age (Old group, 17.2 ± 0.9 years, n = 6 mares) were used to investigate the effect of age. In Experiment 2, the luteal and embryonic parameters were compared between mares with minimal (Mild group, endometrial category I, n = 9 mares) and severe (Severe group, endometrial category III, n = 7 mares) endometrial degeneration. The Old and Severe groups had greater (p ≤ 0.04) total CL area and reduced luteal vascularity (p ≤ 0.04) than the Young and Mild groups, respectively. However, P4 levels and CL area with blood signals were similar (p ≥ 0.8) between the groups. A negative effect of age (p < 0.01), but not of endometrial degeneration (p = 0.6), was found for the embryonic vesicle diameter. The conceptus mobility was high (p > 0.1) until day 14 of gestation in the Severe group, while a reduced number of changes of the embryo location was detected earlier (p < 0.05) in the Old group. In conclusion, the newly formed CL of aged mares and mares with severe endometrial degeneration suffered a structural remodelling to safeguard the local blood supply and the continuous P4 output during early gestation. Moreover, an earlier reduction of the embryonic mobility and a delayed development of the conceptus were associated with advanced age, regardless of the degree of endometrial degeneration.en
dc.description.affiliationDepartment of Animal Reproduction and Veterinary Radiology São Paulo State University (UNESP) School of Veterinary Medicine and Animal Science
dc.description.affiliationVeterinary Science Graduate Program University of Franca
dc.description.affiliationDepartment of Veterinary Clinics São Paulo State University (UNESP) School of Veterinary Medicine and Animal Science
dc.description.affiliationUnespDepartment of Animal Reproduction and Veterinary Radiology São Paulo State University (UNESP) School of Veterinary Medicine and Animal Science
dc.description.affiliationUnespDepartment of Veterinary Clinics São Paulo State University (UNESP) School of Veterinary Medicine and Animal Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2008/54929-2
dc.description.sponsorshipIdFAPESP: 2009/52575-1
dc.format.extent571-579
dc.identifierhttp://dx.doi.org/10.1111/rda.13396
dc.identifier.citationReproduction in Domestic Animals, v. 54, n. 3, p. 571-579, 2019.
dc.identifier.doi10.1111/rda.13396
dc.identifier.issn1439-0531
dc.identifier.issn0936-6768
dc.identifier.lattes0042905415711199
dc.identifier.orcid0000-0002-2245-800X
dc.identifier.scopus2-s2.0-85059702114
dc.identifier.urihttp://hdl.handle.net/11449/188589
dc.language.isoeng
dc.relation.ispartofReproduction in Domestic Animals
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectconceptus
dc.subjectcorpus luteum
dc.subjectDoppler ultrasonography
dc.subjectpregnancy
dc.subjectprogesterone
dc.subjectuterus
dc.titleLuteal vascularity and embryo dynamics in mares during early gestation: Effect of age and endometrial degenerationen
dc.typeArtigo
unesp.author.lattes0042905415711199[6]
unesp.author.orcid0000-0001-6908-3463[1]
unesp.author.orcid0000-0002-2245-800X[6]

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Artigos - Reprodução Animal e Radiologia Veterinária - FMVZ
Artigos - Clínica Veterinária - FMVZ