LED phototherapy in full-thickness burns induced by CO2 laser in rats skin

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dc.contributor.authorda Silva Melo, Milene
dc.contributor.authorAlves, Leandro Procópio
dc.contributor.authorFernandes, Adriana Barrinha
dc.contributor.authorCarvalho, Henrique Cunha
dc.contributor.authorde Lima, Carlos José
dc.contributor.authorMunin, Egberto
dc.contributor.authorGomes, Mônica Fernandes [UNESP]
dc.contributor.authorSalgado, Miguel Angel Castillo [UNESP]
dc.contributor.authorZângaro, Renato Amaro
dc.contributor.institutionTechnology and Education CITÉ
dc.contributor.institutionCamilo Castelo Branco University (UNICASTELO)
dc.contributor.institutionAnhembi Morumbi University (UAM)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:19:43Z
dc.date.available2018-12-11T17:19:43Z
dc.date.issued2018-09-01
dc.description.abstractMany studies have been conducted on the treatment of burns because they are important in morbidity and mortality. These studies are mainly focused on improving care and quality of life of patients. The aim of this study was evaluate the LED phototherapy effects in rats skin full-thickness burns induced by CO2 laser. The animals were divided in NT group that did not received any treatment and LED group that received LED irradiation at 685 nm, 220 mW, and 4.5 J/cm2 during 40 s by burned area. Biopsies were obtained after 7, 14, and 21 days of treatment and submitted to histological and immunohistochemical analysis. The LED phototherapy shows anti-inflammatory effects, improves angiogenesis, and stimulates the migration and proliferation of fibroblasts. The T CD8+ lymphocytes were more common in burned areas compared to T CD4+ lymphocytes since statistically significant differences were observed in the LED group compared to the NT group after 7 days of treatment. These results showed that LED phototherapy performs positive influence in full-thickness burns repair from the healing process modulated by cellular immune response. The obtained results allowed inferring that burns exhibit a characteristic cell immune response and this cannot be extrapolated to other wounds such as incision and wounds induced by punch, among others.en
dc.description.affiliationCenter for Innovation Technology and Education CITÉ
dc.description.affiliationCamilo Castelo Branco University (UNICASTELO)
dc.description.affiliationAnhembi Morumbi University (UAM)
dc.description.affiliationSão José dos Campos Dental School Bioscience Center for Special Health Care (CEBAPE) Institute of Science and Technology Paulista State University (ICT-UNESP)
dc.description.affiliationHistology Laboratory São José dos Campos Dental School Institute of Science and Technology Paulista State University (ICT-UNESP)
dc.description.affiliationUnespSão José dos Campos Dental School Bioscience Center for Special Health Care (CEBAPE) Institute of Science and Technology Paulista State University (ICT-UNESP)
dc.description.affiliationUnespHistology Laboratory São José dos Campos Dental School Institute of Science and Technology Paulista State University (ICT-UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 09/53509-2
dc.description.sponsorshipIdFAPESP: 11/50468-3
dc.format.extent1537-1547
dc.identifierhttp://dx.doi.org/10.1007/s10103-018-2515-8
dc.identifier.citationLasers in Medical Science, v. 33, n. 7, p. 1537-1547, 2018.
dc.identifier.doi10.1007/s10103-018-2515-8
dc.identifier.file2-s2.0-85046032477.pdf
dc.identifier.issn1435-604X
dc.identifier.issn0268-8921
dc.identifier.lattes8235700830441386
dc.identifier.lattes1274225455678400
dc.identifier.scopus2-s2.0-85046032477
dc.identifier.urihttp://hdl.handle.net/11449/176234
dc.language.isoeng
dc.relation.ispartofLasers in Medical Science
dc.relation.ispartofsjr0,713
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCO2 laser
dc.subjectFull-thickness burns
dc.subjectHistology
dc.subjectImmunohistochemistry
dc.subjectLED phototherapy
dc.subjectLymphocytes T CD4+ and T CD8+
dc.subjectWound healing
dc.titleLED phototherapy in full-thickness burns induced by CO2 laser in rats skinen
dc.typeArtigo
unesp.advisor.lattes8235700830441386
unesp.author.lattes1274225455678400

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