The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression

dc.contributor.authorSilva, Marcelo Jose Dias [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorDa Silva, Marcelo Aparecido
dc.contributor.authorPaiotti, Ana Paula Ribeiro
dc.contributor.authorPastrelo, Mauricio Mercaldi
dc.contributor.authorRuiz, Pedro Luiz Menin
dc.contributor.authorDe Moura, Carolina Foot Gomes
dc.contributor.authorOshima, Celina Tizuko Fujiyama
dc.contributor.authorRibeiro, Daniel Araki
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUNIFAL
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:15:22Z
dc.date.available2018-12-11T17:15:22Z
dc.date.issued2018-04-01
dc.description.abstractThe aim of this study was to evaluate the preventive and/or protective action of Mimosa caesalpiniifolia (M. caesalpiniifolia) following experimental colitis in rats. The rats were randomized into ten groups (n=10 per group), as follows: G1 - Sham group:; G2 - TNBS group; G3, G4 -colitis and treated with hydroalcoholic extract of M. caesalpiniifolia 250 mg/kg/day after and before/after inducing colitis, respectively; G5, G6 - colitis and treated with hydroalcoholic extract of M. caesalpiniifolia at 125 mg/kg/day after and before/after inducing colitis respectively; G7,G8 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/after inducing colitis, respectively; G9,G10 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/after inducing colitis, respectively. Rats treated with hydroalcoholic extract of M. caesalpiniifolia for both doses showed lower tissue damage in the distal colon. Ethylacetate fraction was effective at the highest dose only when administrated after inducing colitis. A downregulation of COX-2 was detected to rats suffering colitis and treated with M. caesalpiniifolia at high dose. On the other hand, TNF-alpha immunoexpression decreased in groups treated with M. caesalpiniifolia at low dose after inducing colitis. In summary, our results suggest that M. caesalpiniifolia attenuated the lesions of the colon, reduced inflammation, and modulates the expression of COX-2 and TNF-α during chronic colitis induced by TNBS when using for therapeutic purposes on a dose-dependent manner.en
dc.description.affiliationSao Paulo State University UNESP Campus Litoral Paulista
dc.description.affiliationDepartment of Food and Drug Federal University of Alfenas UNIFAL
dc.description.affiliationDepartment of Pathology
dc.description.affiliationDepartment of Biosciences Federal University of Sao Paulo UNIFESP, Av. Ana Costa 95
dc.description.affiliationUnespSao Paulo State University UNESP Campus Litoral Paulista
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent196-204
dc.identifierhttp://dx.doi.org/10.1055/s-0043-119750
dc.identifier.citationDrug Research, v. 68, n. 4, p. 196-204, 2018.
dc.identifier.doi10.1055/s-0043-119750
dc.identifier.issn2194-9387
dc.identifier.issn2194-9379
dc.identifier.scopus2-s2.0-85031398144
dc.identifier.urihttp://hdl.handle.net/11449/175338
dc.language.isoeng
dc.relation.ispartofDrug Research
dc.relation.ispartofsjr0,334
dc.relation.ispartofsjr0,334
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCOX-2
dc.subjectinflammatory bowel disease
dc.subjectmimosa
dc.subjectTNBS-colitis
dc.subjectTNF-alpha
dc.titleThe Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expressionen
dc.typeArtigo

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