Plant extracts: Initial screening, identification of bioactive compounds and effect against Candida albicans biofilms

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dc.contributor.authorLourenção Brighenti, Fernanda [UNESP]
dc.contributor.authorSalvador, Marcos José
dc.contributor.authorGontijo, Aline Vidal Lacerda
dc.contributor.authorDelbem, Alberto Carlos Botazzo [UNESP]
dc.contributor.authorDelbem, Ádina Cléia Botazzo [UNESP]
dc.contributor.authorSoares, Cristina Pacheco
dc.contributor.authorDe Oliveira, Maria Alcionéia Carvalho [UNESP]
dc.contributor.authorGirondi, Camila Miorelli [UNESP]
dc.contributor.authorKoga-Ito, Cristiane Yumi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Do Vale Do Paraíba-UNIVAP
dc.date.accessioned2018-12-11T17:30:48Z
dc.date.available2018-12-11T17:30:48Z
dc.date.issued2017-01-01
dc.description.abstractAim: This study screened plants from Brazilian Pantanal for Candida albicans antibiofilm activity. Material & Methods: Sixty extracts were obtained from ten plants using different extraction methods. Antifungal activity was assessed. Effects on biofilm inhibition and disruption and cytotoxicity were also evaluated. The most active extract was chemically characterized. Results: Buchenavia tomentosa ethanolic extract showed noticeable antifungal activity and was selected for biofilm experiments. Subinhibitory concentration of extract inhibited fungal adhesion. Maximum killing reached 90% of C. albicans cells in suspension and 65% of cells in biofilms. The active extract was noncytotoxic. Chemical characterization showed the presence of phenols. Ellagic and gallic acids showed activity on C. albicans. Conclusion: B. tomentosa extract and its isolated compound, ellagic acid, presented antibiofilm activity and low toxicity.en
dc.description.affiliationFaculty of Dentistry Univ. Estadual Paulista/UNESP, Araraquara, R. Humaitá, 1680
dc.description.affiliationInstitute of Biology University of Campinas/UNICAMP, Postal Box 6109
dc.description.affiliationFaculty of Dentistry Univ. Estadual Paulista/UNESP, Araçatuba, R. José Bonifácio 1193
dc.description.affiliationUniversidade Do Vale Do Paraíba-UNIVAP, Av. Shishima Hifumi, 2911
dc.description.affiliationInstitute of Science and Technology Univ. Estadual Paulista/UNESP São José Dos Campos, Av. Eng. Francisco José Longo, 777
dc.description.affiliationUnespFaculty of Dentistry Univ. Estadual Paulista/UNESP, Araraquara, R. Humaitá, 1680
dc.description.affiliationUnespFaculty of Dentistry Univ. Estadual Paulista/UNESP, Araçatuba, R. José Bonifácio 1193
dc.description.affiliationUnespInstitute of Science and Technology Univ. Estadual Paulista/UNESP São José Dos Campos, Av. Eng. Francisco José Longo, 777
dc.format.extent15-27
dc.identifierhttp://dx.doi.org/10.2217/fmb-2016-0094
dc.identifier.citationFuture Microbiology, v. 12, n. 1, p. 15-27, 2017.
dc.identifier.doi10.2217/fmb-2016-0094
dc.identifier.issn1746-0921
dc.identifier.issn1746-0913
dc.identifier.lattes6543563161403421
dc.identifier.orcid0000-0002-2416-2173
dc.identifier.scopus2-s2.0-85007012868
dc.identifier.urihttp://hdl.handle.net/11449/178530
dc.language.isoeng
dc.relation.ispartofFuture Microbiology
dc.relation.ispartofsjr1,270
dc.relation.ispartofsjr1,270
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectantifungal agents
dc.subjectbioactive compounds
dc.subjectbiofilms
dc.subjectCandida albicans
dc.titlePlant extracts: Initial screening, identification of bioactive compounds and effect against Candida albicans biofilmsen
dc.typeArtigo
unesp.author.lattes0421571920582994[4]
unesp.author.lattes6543563161403421[9]
unesp.author.orcid0000-0002-8159-4853[4]
unesp.author.orcid0000-0002-2416-2173[9]

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Artigos - Odontologia Infantil e Social - FOA
Artigos - Biociências e Diagnóstico Bucal - ICT