Voltammetric determination of ethinylestradiol using screen-printed electrode modified with functionalized graphene, graphene quantum dots and magnetic nanoparticles coated with molecularly imprinted polymers

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dc.contributor.authorSantos, Anderson M.
dc.contributor.authorWong, Ademar [UNESP]
dc.contributor.authorPrado, Thiago M.
dc.contributor.authorFava, Elson L.
dc.contributor.authorFatibello-Filho, Orlando
dc.contributor.authorSotomayor, Maria D. P. T. [UNESP]
dc.contributor.authorMoraes, Fernando C.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionINCT DATREM
dc.date.accessioned2021-06-25T12:29:54Z
dc.date.available2021-06-25T12:29:54Z
dc.date.issued2021-03-01
dc.description.abstractThe present work reports the development of a sensitive and selective method for ethinylestradiol detection using screen-printed electrode (SPE) modified with functionalized graphene (FG), graphene quantum dots (GQDs) and magnetic nanoparticles coated with molecularly imprinted polymers (mag@MIP). The performance of the mag@MIP sensor was compared with that of a non-molecularly imprinted sensor (mag@NIP). Chemical and physical characterizations of the mag@NIP and mag@MIP sensors were performed using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and Brunauer-Emmett-Teller (BET) techniques. The electrochemical behavior of the electrodes investigated, which included (mag@MIP)-GQDs-FG-NF/SPE, (mag@NIP)-GQDs-FG-NF/SPE, GQDs-FG-NF/SPE and FG-NF/SPE, was evaluated by cyclic voltammetry. The results obtained show a significant increase in peak current magnitude for (mag@MIP)-GQDs-FG-NF/SPE. Using square wave voltammetry experiments, the efficiency of the (mag@MIP)-GQDs-FG-NF/SPE sensor was also tested under optimized conditions. The linear response range obtained for ethinylestradiol concentration was 10 nmol L-1 to 2.5 mu mol L-1, with limit of detection of 2.6 nmol L-1. The analytical signal of the (mag@MIP)-GQDs-FG-NF/SPE sensor suffered no interference from different compounds and the sensor exhibited good repeatability. The proposed sensor was successfully applied for ethynilestradiol detection in river water, serum and urine samples, where recovery rates between 96 to 105% and 97-104% were obtained for environmental and biological samples, respectively.en
dc.description.affiliationUniv Fed Sao Carlos, Dept Chem, Rod Washington Luis Km 235,POB 676, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationState Univ Sao Paulo, Inst Chem, Dept Analyt Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationINCT DATREM, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespState Univ Sao Paulo, Inst Chem, Dept Analyt Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPROJ. AUX/PE/PROEX
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdCNPq: 150184/2019-0
dc.description.sponsorshipIdCNPq: 405546/2018-1
dc.description.sponsorshipIdCNPq: 408050/2018-7
dc.description.sponsorshipIdFAPESP: 2017/10118-0
dc.description.sponsorshipIdFAPESP: 2016/10012-4
dc.description.sponsorshipIdFAPESP: 2019/00677-7
dc.description.sponsorshipIdFAPESP: 2020/01050-5
dc.description.sponsorshipIdPROJ. AUX/PE/PROEX: 0674/2018 CAPES
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1016/j.talanta.2020.121804
dc.identifier.citationTalanta. Amsterdam: Elsevier, v. 224, 9 p., 2021.
dc.identifier.doi10.1016/j.talanta.2020.121804
dc.identifier.issn0039-9140
dc.identifier.urihttp://hdl.handle.net/11449/209809
dc.identifier.wosWOS:000600787800034
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTalanta
dc.sourceWeb of Science
dc.subjectMIP
dc.subjectGraphene
dc.subjectQuantum dots
dc.subjectScreen-printed electrode
dc.subjectEthinylestradiol
dc.titleVoltammetric determination of ethinylestradiol using screen-printed electrode modified with functionalized graphene, graphene quantum dots and magnetic nanoparticles coated with molecularly imprinted polymersen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-1249-1367[2]

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