Proliferating cell nuclear antigen immunoreaction in adrenal-tumors

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dc.contributor.authorDamiani, D.
dc.contributor.authorManna, T. D.
dc.contributor.authorAquino, LGW
dc.contributor.authorAlves, F.
dc.contributor.authorLongatto, A.
dc.contributor.authorKanamura, C. T.
dc.contributor.authorSetian, N.
dc.contributor.institutionSAO PAULO STATE PUBL HLTH SERV
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:56:59Z
dc.date.available2015-03-18T15:56:59Z
dc.date.issued1995-07-01
dc.description.abstractAims mid background: We studied, retrospectively, 33 cases of adrenal tumors of children at the Pediatric Endocrinology Unit, Children's Institute, Sao Paulo State University Medical School, from 1975 to 1993. Ail patients had at least 2 years of follow-up with a few exceptions. Methods: Clinical follow-up data were correlated with histopathologic review, laboratory data and cell kinetic evaluation (based on detection of proliferating cell nuclear antigens). Results: With one exception, all the patients had presented signs of androgen production and had high levels of dehydro-epiandrosterone-sulfate. Tumor weight evaluation represented a good parameter of neoplasm evolution: of 19 cases weighing less than 250 g, 17 had no evidence of disease after surgery, and 2 had an unfavorable prognosis. Of 14 cases weighing more than 250 g, only 1 had no evidence of disease and 13 had an unfavorable evolution. Conclusions: Proliferating cell nuclear antigen (PCNA) was not helpful to evaluate adrenal neoplasm evolution: our study did not show any correlation between PCNA score and prognosis.en
dc.description.affiliationSAO PAULO STATE PUBL HLTH SERV,ADOLFO LUTZ INST,DIV PATHOL,BR-01246902 SAO PAULO,SP,BRAZIL
dc.description.affiliationSAO PAULO STATE UNIV,SCH MED,CHILDRENS INST,PEDIAT ENDOCRINOL UNIT,SAO PAULO,BRAZIL
dc.description.affiliationSAO PAULO STATE UNIV,SCH MED,DEPT PATHOL,SAO PAULO,BRAZIL
dc.description.affiliationUnespSAO PAULO STATE UNIV,SCH MED,CHILDRENS INST,PEDIAT ENDOCRINOL UNIT,SAO PAULO,BRAZIL
dc.description.affiliationUnespSAO PAULO STATE UNIV,SCH MED,DEPT PATHOL,SAO PAULO,BRAZIL
dc.format.extent273-277
dc.identifier.citationTumori. Milan: Casa Editrice Ambrosiana, v. 81, n. 4, p. 273-277, 1995.
dc.identifier.issn0300-8916
dc.identifier.urihttp://hdl.handle.net/11449/117827
dc.identifier.wosWOS:A1995TA49900012
dc.language.isoeng
dc.publisherCasa Editrice Ambrosiana
dc.relation.ispartofTumori
dc.relation.ispartofjcr1.304
dc.relation.ispartofsjr0,396
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectADRENAL NEOPLASMSen
dc.subjectPROLIFERATING CELL NUCLEAR ANTIGENen
dc.subjectCELL KINETICSen
dc.subjectPEDIATRIC NEOPLASMSen
dc.subjectENDOCRINOLOGIC NEOPLASMSen
dc.titleProliferating cell nuclear antigen immunoreaction in adrenal-tumorsen
dc.typeArtigo
dcterms.rightsHolderCasa Editrice Ambrosiana

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