Topical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Aging

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dc.contributor.authorOliveira, Marcela B. [UNESP]
dc.contributor.authorPrado, Alice Haddad do [UNESP]
dc.contributor.authorBernegossi, Jessica [UNESP]
dc.contributor.authorSato, Claudia S. [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorScarpa, Maria Virginia [UNESP]
dc.contributor.authorLeonardi, Gislaine Ricci
dc.contributor.authorFriberg, Stig E.
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionNorwegian Univ Sci & Technol NTNU
dc.date.accessioned2014-12-03T13:11:44Z
dc.date.available2014-12-03T13:11:44Z
dc.date.issued2014-01-01
dc.description.abstractThe objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (SGC) as oil phase, and water in the ratios 30 : 25 : 45 and 40 : 50 : 10 with (OLS nu = RP-loaded opaque liquid system and TLS nu = RP-loaded transparent liquid system, respectively) and without (OLS and TLS, respectively) RP were studied. Samples were characterized using polarized light microscopy (PLM) and rheology analysis. In vitro safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays. In vitro antioxidant activity was performed by the DPPH method. PLM analysis showed the presence of lamellar LCS just to TLS. Regardless of the presence of RP, the rheological studies showed the pseudoplastic behavior of the formulations. The results showed that the incorporation of RP in LCS improved the safety profile of the drug. In vitro antioxidant activity suggests that LCS presented a higher capacity to maintain the antioxidant activity of RP. PFS-based systems may be a promising platform for RP topical application for the treatment of skin aging.en
dc.description.affiliationUNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationNorwegian Univ Sci & Technol NTNU, Ugelstad Lab, N-7491 Trondheim, Norway
dc.description.affiliationUnespUNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Cientifico (PADC-UNESP)
dc.format.extent7
dc.identifierhttp://dx.doi.org/10.1155/2014/632570
dc.identifier.citationBiomed Research International. New York: Hindawi Publishing Corporation, 7 p., 2014.
dc.identifier.doi10.1155/2014/632570
dc.identifier.fileWOS000333635900001.pdf
dc.identifier.issn2314-6133
dc.identifier.lattes1427125996716282
dc.identifier.urihttp://hdl.handle.net/11449/113478
dc.identifier.wosWOS:000333635900001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofBioMed Research International
dc.relation.ispartofjcr2.583
dc.relation.ispartofsjr0,935
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleTopical Application of Retinyl Palmitate-Loaded Nanotechnology-Based Drug Delivery Systems for the Treatment of Skin Agingen
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes1427125996716282
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas