Antitrypanosomal acetylene fatty acid derivatives from the seeds of porcelia macrocarpa (annonaceae)

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dc.contributor.authorSantos, Luciana de A. [UNESP]
dc.contributor.authorCavalheiro, Alberto J. [UNESP]
dc.contributor.authorTempone, Andre G.
dc.contributor.authorCorrea, Daniela S.
dc.contributor.authorAlexandre, Tatiana R.
dc.contributor.authorQuintiliano, Natalia F.
dc.contributor.authorRodrigues-Oliveira, Andre F.
dc.contributor.authorOliveira-Silva, Diogo
dc.contributor.authorMartins, Roberto Carlos C.
dc.contributor.authorLago, Joao Henrique G.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAdolfo Lutz Inst
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.date.accessioned2015-10-21T20:24:02Z
dc.date.available2015-10-21T20:24:02Z
dc.date.issued2015-05-01
dc.description.abstractChagas'disease is caused by a parasitic protozoan and affects the poorest population in the world, causing high mortality and morbidity. As a result of the toxicity and long duration of current treatments, the discovery of novel and more efficacious drugs is crucial. In this work, the hexane extract from seeds of Porcelia macrocarpa R.E. Fries (Annonaceae) displayed in vitro antitrypanosomal activity against trypomastigote forms of T. cruzi by the colorimetric MTT assay (IC50 of 65.44 g/mL). Using chromatographic fractionation over SiO2, this extract afforded a fraction composed by one active compound (IC50 of 10.70 mu g/mL), which was chemically characterized as 12,14-octadecadiynoic acid (macrocarpic acid). Additionally, two new inactive acetylene compounds (,'-dimacro-carpoyl--oleylglycerol and -macrocarpoyl-'-oleylglycerol) were also isolated from the hexane extract. The complete characterization of the isolated compounds was performed by analysis of NMR and MS data as well as preparation of derivatives.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Nucleo Bioensaios Biossintese &Ecofisiol Prod Na, BR-14800060 Araraquara, SP, Brazil
dc.description.affiliationAdolfo Lutz Inst, Ctr Parasitol &Micol, BR-01246902 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim &Farmaceut, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Pesquisa Prod Nat, BR-21941902 Rio De Janeiro, RJ, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Departamento de Química Orgânica, Inst Quim, Nucleo Bioensaios Biossintese &Ecofisiol Prod Na, BR-14800060 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 300546/2012-2
dc.description.sponsorshipIdCNPq: 471458/2012-0
dc.description.sponsorshipIdFAPESP: 1998/01735-2
dc.description.sponsorshipIdFAPESP: 2011/51739-0
dc.description.sponsorshipIdFAPESP: 2012/18756-1
dc.format.extent8168-8180
dc.identifierhttp://www.mdpi.com/1420-3049/20/5/8168
dc.identifier.citationMolecules, v. 20, n. 5, p. 8168-8180, 2015.
dc.identifier.doi10.3390/molecules20058168
dc.identifier.fileWOS000357157600044.pdf
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/11449/129118
dc.identifier.wosWOS:000357157600044
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofMolecules
dc.relation.ispartofjcr3.098
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPorcelia macrocarpaen
dc.subjectAnnonaceaeen
dc.subjectAcetylene derivativesen
dc.subjectTrypanosoma cruzien
dc.titleAntitrypanosomal acetylene fatty acid derivatives from the seeds of porcelia macrocarpa (annonaceae)en
dc.typeArtigo
dcterms.rightsHolderMdpi Ag
unesp.author.lattes2518006820764120[2]
unesp.author.orcid0000-0001-8214-9957[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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