Expression of nonclassical molecule human leukocyte antigen-G in oral lesions

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dc.contributor.authorFregonezi, Paula A. G. [UNESP]
dc.contributor.authorSilva, Tarsia G. A. [UNESP]
dc.contributor.authorSimoes, Renata T.
dc.contributor.authorMoreau, Philipe
dc.contributor.authorCarosella, Edgardo D.
dc.contributor.authorKlaey, Carla P. M.
dc.contributor.authorGoncalves, Maria A. G.
dc.contributor.authorSoares, Edson G.
dc.contributor.authorSouto, Francisco
dc.contributor.authorDonadi, Eduardo A.
dc.contributor.authorSoares, Christiane P. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionServ Rech Hematoimmunol
dc.contributor.institutionUniv Fed Mato Grosso
dc.date.accessioned2014-05-20T13:23:56Z
dc.date.available2014-05-20T13:23:56Z
dc.date.issued2012-03-01
dc.description.abstractIntroduction: Human leukocyte antigen (HLA)-G is a nonclassic class I molecule that acts as a modulator of immune responses, and the expression of these molecules in virus-infected cells has been associated with subversion of the immune response.Objective: In this study, we performed a cross-sectional study, systematically comparing the expression of the HLA-G in benign, premalignant, and malignant oral lesions and correlating it with the presence of high-risk and low-risk human papillomavirus (HPV) types.Specimens and Methods: Oral biopsies were collected from 51 patients and analyzed by immunohistochemistry using anti HLA-G antibody. Human papillomavirus detection and typing from oral biopsies were obtained by polymerase chain reaction using GP5+/GP6+ and specific primers.Results: The 51 biopsies were stratified into 3 groups according to lesion grade: oral benign lesions (oral hyperplasia and papilloma, n = 16), oral premalignant lesions (oral leukoplakia with dysplasia and lichen planus, n = 17), and malignant lesions (oral squamous cell carcinoma, n = 18). Human leukocyte antigen G overexpression was mainly observed in benign and premalignant oral lesions but was not related to HPV infection (P>.05). on the other hand, HPV DNA was detected in 24 (47%) oral lesions, mainly in benign and premalignant lesions, with the most frequent type detected being high-risk HPV type.Conclusion: The HLA-G molecule was expressed in a significant number of benign oral lesions and was not correlated with HPV infection or oral cancer. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo State, Dept Clin Anal, Sch Pharmaceut Sci Araraquara, UNESP, BR-14801902 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Div Clin Immunol, Dept Med, Sch Med Ribeirao Preto, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Pathol, Sch Med Ribeirao Preto, São Paulo, Brazil
dc.description.affiliationServ Rech Hematoimmunol, CEA I2BM, Paris, France
dc.description.affiliationUniv Fed Mato Grosso, Dept Internal Med, Cuiaba, Mato Grosso, Brazil
dc.description.affiliationUnespUniv São Paulo State, Dept Clin Anal, Sch Pharmaceut Sci Araraquara, UNESP, BR-14801902 São Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent193-198
dc.identifierhttp://dx.doi.org/10.1016/j.amjoto.2010.08.001
dc.identifier.citationAmerican Journal of Otolaryngology. Philadelphia: W B Saunders Co-elsevier Inc, v. 33, n. 2, p. 193-198, 2012.
dc.identifier.doi10.1016/j.amjoto.2010.08.001
dc.identifier.issn0196-0709
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.urihttp://hdl.handle.net/11449/7316
dc.identifier.wosWOS:000301404500001
dc.language.isoeng
dc.publisherW B Saunders Co-elsevier Inc
dc.relation.ispartofAmerican Journal of Otolaryngology
dc.relation.ispartofjcr1.046
dc.relation.ispartofsjr0,590
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleExpression of nonclassical molecule human leukocyte antigen-G in oral lesionsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderW B Saunders Co-elsevier Inc
unesp.author.lattes1768025290373669[11]
unesp.author.orcid0000-0002-2529-4119[9]
unesp.author.orcid0000-0002-9457-9601[10]
unesp.author.orcid0000-0003-1740-7360[11]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas