Expression of nonclassical molecule human leukocyte antigen-G in oral lesions
dc.contributor.author | Fregonezi, Paula A. G. [UNESP] | |
dc.contributor.author | Silva, Tarsia G. A. [UNESP] | |
dc.contributor.author | Simoes, Renata T. | |
dc.contributor.author | Moreau, Philipe | |
dc.contributor.author | Carosella, Edgardo D. | |
dc.contributor.author | Klaey, Carla P. M. | |
dc.contributor.author | Goncalves, Maria A. G. | |
dc.contributor.author | Soares, Edson G. | |
dc.contributor.author | Souto, Francisco | |
dc.contributor.author | Donadi, Eduardo A. | |
dc.contributor.author | Soares, Christiane P. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Serv Rech Hematoimmunol | |
dc.contributor.institution | Univ Fed Mato Grosso | |
dc.date.accessioned | 2014-05-20T13:23:56Z | |
dc.date.available | 2014-05-20T13:23:56Z | |
dc.date.issued | 2012-03-01 | |
dc.description.abstract | Introduction: Human leukocyte antigen (HLA)-G is a nonclassic class I molecule that acts as a modulator of immune responses, and the expression of these molecules in virus-infected cells has been associated with subversion of the immune response.Objective: In this study, we performed a cross-sectional study, systematically comparing the expression of the HLA-G in benign, premalignant, and malignant oral lesions and correlating it with the presence of high-risk and low-risk human papillomavirus (HPV) types.Specimens and Methods: Oral biopsies were collected from 51 patients and analyzed by immunohistochemistry using anti HLA-G antibody. Human papillomavirus detection and typing from oral biopsies were obtained by polymerase chain reaction using GP5+/GP6+ and specific primers.Results: The 51 biopsies were stratified into 3 groups according to lesion grade: oral benign lesions (oral hyperplasia and papilloma, n = 16), oral premalignant lesions (oral leukoplakia with dysplasia and lichen planus, n = 17), and malignant lesions (oral squamous cell carcinoma, n = 18). Human leukocyte antigen G overexpression was mainly observed in benign and premalignant oral lesions but was not related to HPV infection (P>.05). on the other hand, HPV DNA was detected in 24 (47%) oral lesions, mainly in benign and premalignant lesions, with the most frequent type detected being high-risk HPV type.Conclusion: The HLA-G molecule was expressed in a significant number of benign oral lesions and was not correlated with HPV infection or oral cancer. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved. | en |
dc.description.affiliation | Univ São Paulo State, Dept Clin Anal, Sch Pharmaceut Sci Araraquara, UNESP, BR-14801902 São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Div Clin Immunol, Dept Med, Sch Med Ribeirao Preto, São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Dept Pathol, Sch Med Ribeirao Preto, São Paulo, Brazil | |
dc.description.affiliation | Serv Rech Hematoimmunol, CEA I2BM, Paris, France | |
dc.description.affiliation | Univ Fed Mato Grosso, Dept Internal Med, Cuiaba, Mato Grosso, Brazil | |
dc.description.affiliationUnesp | Univ São Paulo State, Dept Clin Anal, Sch Pharmaceut Sci Araraquara, UNESP, BR-14801902 São Paulo, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.format.extent | 193-198 | |
dc.identifier | http://dx.doi.org/10.1016/j.amjoto.2010.08.001 | |
dc.identifier.citation | American Journal of Otolaryngology. Philadelphia: W B Saunders Co-elsevier Inc, v. 33, n. 2, p. 193-198, 2012. | |
dc.identifier.doi | 10.1016/j.amjoto.2010.08.001 | |
dc.identifier.issn | 0196-0709 | |
dc.identifier.lattes | 1768025290373669 | |
dc.identifier.orcid | 0000-0003-1740-7360 | |
dc.identifier.uri | http://hdl.handle.net/11449/7316 | |
dc.identifier.wos | WOS:000301404500001 | |
dc.language.iso | eng | |
dc.publisher | W B Saunders Co-elsevier Inc | |
dc.relation.ispartof | American Journal of Otolaryngology | |
dc.relation.ispartofjcr | 1.046 | |
dc.relation.ispartofsjr | 0,590 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Expression of nonclassical molecule human leukocyte antigen-G in oral lesions | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | W B Saunders Co-elsevier Inc | |
unesp.author.lattes | 1768025290373669[11] | |
unesp.author.orcid | 0000-0002-2529-4119[9] | |
unesp.author.orcid | 0000-0002-9457-9601[10] | |
unesp.author.orcid | 0000-0003-1740-7360[11] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Análises Clínicas - FCF | pt |
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