Effects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horses

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dc.contributor.authorBrosnan, Robert J.
dc.contributor.authorSteffey, Eugene P.
dc.contributor.authorEscobar, André [UNESP]
dc.contributor.institutionUniv Calif Davis
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:14:15Z
dc.date.available2014-05-20T13:14:15Z
dc.date.issued2012-07-01
dc.description.abstractObjective To test the hypothesis that hypercapnic hyperpnea produced using endotracheal insufflation with 5-10% CO2 in oxygen could be used to shorten anesthetic recovery time in horses, and that recovery from sevoflurane would be faster than from isoflurane.Study design Randomized crossover study design.Animals Eight healthy adult horses.Methods After 2 hours' administration of constant 1.2 times MAC isoflurane or sevoflurane, horses were disconnected from the anesthetic circuit and administered 0, 5, or 10% CO2 in balance O-2 via endotracheal tube insufflation. End-tidal gas samples were collected to measure anesthetic washout kinetics, and arterial and venous blood samples were collected to measure respiratory gas partial pressures. Horses recovered in padded stalls without assistance, and each recovery was videotaped and evaluated by reviewers who were blinded to the anesthetic agent and insufflation treatment used.Results Compared to isoflurane, sevoflurane caused greater hypoventilation and was associated with longer times until standing recovery. CO2 insufflation significantly decreased anesthetic recovery time compared to insufflation with O-2 alone without significantly increasing PaCO2. Pharmacokinetic parameters during recovery from isoflurane with CO2 insufflation were statistically indistinguishable from sevoflurane recovery without CO2. Neither anesthetic agent nor insufflation treatment affected recovery quality from anesthesia.Conclusions and clinical relevance Hypercapnic hyperpnea decreases time to standing without influencing anesthetic recovery quality. Although the lower blood gas solubility of sevoflurane should favor a shorter recovery time compared to isoflurane, this advantage is negated by the greater respiratory depression from sevoflurane in horses.en
dc.description.affiliationUniv Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, Davis, CA 95616 USA
dc.description.affiliationSão Paulo State Univ, Dept Vet Clin & Surg, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Vet Clin & Surg, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil
dc.description.sponsorshipCenter for Equine Health
dc.description.sponsorshipState of California pari-mutuel fund
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent335-344
dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.2012.00727.x
dc.identifier.citationVeterinary Anaesthesia and Analgesia. Hoboken: Wiley-blackwell, v. 39, n. 4, p. 335-344, 2012.
dc.identifier.doi10.1111/j.1467-2995.2012.00727.x
dc.identifier.issn1467-2987
dc.identifier.urihttp://hdl.handle.net/11449/1776
dc.identifier.wosWOS:000305514100004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofVeterinary Anaesthesia and Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcarbon dioxideen
dc.subjectHorseen
dc.subjectHypercapniaen
dc.subjectIsofluraneen
dc.subjectrecoveryen
dc.subjectSevofluraneen
dc.titleEffects of hypercapnic hyperpnea on recovery from isoflurane or sevoflurane anesthesia in horsesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Clínica e Cirurgia Veterinária - FCAV