Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae

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Pelizon, A. C. [UNESP]
Kaneno, Ramon [UNESP]
Soares, A. M V C
Meira, D. A.
Sartori, A.

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In this study we investigated the effect of β-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 μg of glucan by i.p. route, were assayed. In vivo β-glucan administration primed spleen cells for a higher production of IL-12 and TNF-α when S. aureus was used as a stimulus. In addition, β-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for β-glucan were observed in this work. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic.



β-glucan, Fungicidal activity, IL-12, NK activity, TNF-α, beta glucan, interleukin 12, tumor necrosis factor alpha, animal cell, animal experiment, cell activity, controlled study, cytokine production, drug effect, female, fungicidal activity, immunomodulation, mouse, natural killer cell, nonhuman, peritoneum cell, Saccharomyces cerevisiae, spleen cell, target cell, Animals, Antifungal Agents, beta-Glucans, Cytokines, Dose-Response Relationship, Drug, Female, Immunologic Factors, Killer Cells, Natural, Mice, Mice, Inbred C57BL, Paracoccidioides

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Physiological Research, v. 54, n. 5, p. 557-564, 2005.