Current advances in immunological studies on the vespidae venom antigen 5: Therapeutic and prophylaxis to hypersensitivity responses

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dc.contributor.authorBazon, Murilo Luiz [UNESP]
dc.contributor.authorSilveira, Lais Helena [UNESP]
dc.contributor.authorSimioni, Patricia Ucelli
dc.contributor.authorBrochetto-Braga, Márcia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFAM
dc.date.accessioned2018-12-11T17:22:02Z
dc.date.available2018-12-11T17:22:02Z
dc.date.issued2018-08-01
dc.description.abstractAlthough systemic reactions caused by allergenic proteins present in venoms affect a small part of the world population, Hymenoptera stings are among the main causes of immediate hypersensitivity responses, with risk of anaphylactic shock. In the attempt to obtain therapeutic treatments and prophylaxis to hypersensitivity responses, interest in the molecular characterization of these allergens has grown in the scientific community due to the promising results obtained in immunological and clinical studies. The present review provides an update on the knowledge regarding the immune response and the therapeutic potential of Antigen 5 derived from Hymenoptera venom. The results confirm that the identification and topology of epitopes, associated with molecular regions that interact with antibodies, are crucial to the improvement of hypersensitivity diagnostic methods.en
dc.description.affiliationLaboratório de Biologia Molecular de Artrópodes-LBMA-IB-RC-UNESP (Univ Estadual Paulista), Av. 24-A, n_ 1515, Bela Vista
dc.description.affiliationDepartamento de Biomedicina Faculdade de Americana FAM, Av. Joaquim Bôer, 733 Jardim Luciane
dc.description.affiliationCentro de Estudos de Venenos e Animais Peçonhentos-CEVAP (Univ Estadual Paulista), Rua José Barbosa de Barros, 1780, Fazenda Experimental Lageado
dc.description.affiliationUnespLaboratório de Biologia Molecular de Artrópodes-LBMA-IB-RC-UNESP (Univ Estadual Paulista), Av. 24-A, n_ 1515, Bela Vista
dc.description.affiliationUnespCentro de Estudos de Venenos e Animais Peçonhentos-CEVAP (Univ Estadual Paulista), Rua José Barbosa de Barros, 1780, Fazenda Experimental Lageado
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipIdFAPESP: #2014/13936-7
dc.description.sponsorshipIdFAPESP: #2017/18422-0
dc.description.sponsorshipIdFAPESP: 2017/07988-2
dc.identifierhttp://dx.doi.org/10.3390/toxins10080305
dc.identifier.citationToxins, v. 10, n. 8, 2018.
dc.identifier.doi10.3390/toxins10080305
dc.identifier.file2-s2.0-85051076829.pdf
dc.identifier.issn2072-6651
dc.identifier.scopus2-s2.0-85051076829
dc.identifier.urihttp://hdl.handle.net/11449/176679
dc.language.isoeng
dc.relation.ispartofToxins
dc.relation.ispartofsjr0,955
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnaphylaxis
dc.subjectAntigen 5
dc.subjectHymenoptera
dc.subjectHypersensitivity
dc.subjectImmune response
dc.titleCurrent advances in immunological studies on the vespidae venom antigen 5: Therapeutic and prophylaxis to hypersensitivity responsesen
dc.typeResenha
unesp.author.orcid0000-0002-7982-0743[4]

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Artigos - Biologia - IBRC
Botucatu - CEVAP - Centro de Estudos de Venenos e Animais Peçonhentos