Effect of platelet-rich plasma on the healing of mandibular defects treated with fresh frozen bone allograft: a radiographic study in dogs

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dc.contributor.authorMessora, Michel R.
dc.contributor.authorNagata, Maria José Hitomi [UNESP]
dc.contributor.authorFucini, Stephen E. [UNESP]
dc.contributor.authorPola, Natalia M. [UNESP]
dc.contributor.authorCampos, Natalia [UNESP]
dc.contributor.authorOliveira, Guillermo C. V. de [UNESP]
dc.contributor.authorBosco, Álvaro Francisco [UNESP]
dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorFurlaneto, Flavia A. C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Ceara
dc.date.accessioned2015-03-18T15:56:07Z
dc.date.available2015-03-18T15:56:07Z
dc.date.issued2014-10-01
dc.description.abstractThe purpose of this study was to radiographically analyze the effect of autologous platelet rich plasma (PRP) on the healing of fresh frozen bone allograft (FFBA) placed in surgically created resection defects in mandibles of dogs. Bilateral resection defects measuring 1.5 cm x 1 cm were surgically created on the inferior border of the mandible in 10 adult male dogs. The defects were randomly divided into three groups: C, FFBA, and FFBA/PRP. In Group C, the defect was filled by blood clot only. In Group FFBA, the defect was filled with particulate fresh frozen bone allograft. In Group FFBA/PRP, it was filled with particulate fresh frozen bone allograft combined with PRP. At 90 days postoperative, standardized radiographs of the mandibles were obtained and results were quantitatively evaluated. Analysis of digitized radiographs indicated that non-PRP grafts were significantly less dense than the PRP grafts. Group FFBA/PRP also presented a statistically greater mineralized tissue area than Groups C and FFBA. Within the limits of this study, it can be concluded that PRP enhanced the healing of FFBA in resection defects in mandibles of dogs.en
dc.description.affiliationUniv Sao Paulo, Sch Dent Ribeirao Preto, Dept Surg & Bucco Maxillofacial Traumatol & Perio, Div Periodont, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Surg & Integrated Clin, Div Periodont,Dent Sch Aracatuba, Aracatuba, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Med Sch Botucatu, Div Anesthesiol, UNESP, Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Ceara, Div Periodont, Sobral, CE, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Surg & Integrated Clin, Div Periodont,Dent Sch Aracatuba, Aracatuba, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Med Sch Botucatu, Div Anesthesiol, UNESP, Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent533-542
dc.identifierhttp://dx.doi.org/10.1563/AAID-JOI-D-12-00175
dc.identifier.citationJournal Of Oral Implantology. Lawrence: Allen Press Inc, v. 40, n. 5, p. 533-542, 2014.
dc.identifier.doi10.1563/AAID-JOI-D-12-00175
dc.identifier.issn0160-6972
dc.identifier.lattes4068921369233125
dc.identifier.lattes8399870097572073
dc.identifier.lattes9831236034935598
dc.identifier.urihttp://hdl.handle.net/11449/117432
dc.identifier.wosWOS:000343785000004
dc.language.isoeng
dc.publisherAllen Press Inc
dc.relation.ispartofJournal Of Oral Implantology
dc.relation.ispartofjcr1.212
dc.relation.ispartofsjr0,569
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbone regenerationen
dc.subjectgrowth factorsen
dc.subjectplateletsen
dc.subjectbone graftingen
dc.titleEffect of platelet-rich plasma on the healing of mandibular defects treated with fresh frozen bone allograft: a radiographic study in dogsen
dc.typeArtigo
dcterms.rightsHolderAllen Press Inc
unesp.author.lattes4068921369233125
unesp.author.lattes8399870097572073
unesp.author.lattes9831236034935598
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Cirurgia e Clínica Integrada - FOA
Artigos - Anestesiologia - FMB