Anxiolytic-like effect of way-100635 microinfusions into the median (but not dorsal) raphe nucleus in mice exposed to the plus-maze: influence of prior test experience

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dc.contributor.authorCanto-De-Souza, A.
dc.contributor.authorNunes-De-Souza, R. L.
dc.contributor.authorRodgers, R. J.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniv Leeds
dc.date.accessioned2014-05-20T13:24:37Z
dc.date.available2014-05-20T13:24:37Z
dc.date.issued2002-02-22
dc.description.abstractStudies in several laboratories have confirmed the anxiolytic potential of a wide range of 5-HT1A receptor antagonists in rats and mice, with recent evidence pointing to a postsynaptic site of action in the ventral hippocampus. It would, therefore, be predicted that blockade of 5-HT1A somatodendritic autoreceptors in the midbrain raphe nuclei should produce anxiogenic-like effects. To test this hypothesis, we investigated the effects of WAY-100635 microinfusions (0, 1.0 or 3.0 mug in 0.1 mul) into the dorsal (DRN) or median (MRN) raphe nuclei on behaviours displayed by male Swiss-Webster mice in the elevated plus-maze. As this test is sensitive to prior experience. The effects of intra-raphe infusions were examined both in maze-naive and maze-experienced subjects. Sessions, were videotaped and subsequently scored for conventional indices of anxiety (open arm avoidance) and locomotor activity (closed arm entries), as well as a range of ethological measures (e.g. risk assessment). In maze-naive mice, intra-MRN (but not intra-DRN) infusions of WAY-100635 (3.0 mug) increased open arm exploration and reduced risk assessment. Importantly, these effects could not be attributed to a general reduction in locomotor activity. A similar, though somewhat weaker, pattern of behavioural change was observed in maze-experienced animals. This unexpected anxiolytic effect of 5-HT1A autoreceptor blockade in the MRN cannot be accounted fur by a disinhibition of 5-HT release in forebrain targets (e.g. hippocampus and amygdala), where stimulation of postsynaptic 5-HT1A receptors enhances anxiety-like responses. However, as the MRN also projects to the periaqueductal gray matter (PAG), an area known to be sensitive to the anti-aversive effects or 5-HT, it is argued that present results may reflect increased 5-HT release at this crucial midbrain locus within the neural circuitry of defense. (C) 2002 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Psicol, BR-13560 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Leeds, Dept Psychol, Lab Behab Pharmacol, Leeds LS2 9JT, W Yorkshire, England
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.format.extent50-59
dc.identifierhttp://dx.doi.org/10.1016/S0006-8993(01)03354-6
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 928, n. 1-2, p. 50-59, 2002.
dc.identifier.doi10.1016/S0006-8993(01)03354-6
dc.identifier.issn0006-8993
dc.identifier.urihttp://hdl.handle.net/11449/7700
dc.identifier.wosWOS:000174374800006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subject5-HT1A receptorpt
dc.subjectanxietypt
dc.subjectmedian raphe nucleuspt
dc.subjectdorsal raphe nucleuspt
dc.subjectelevated plus-mazept
dc.subjectWAY-100635pt
dc.subjectmicept
dc.titleAnxiolytic-like effect of way-100635 microinfusions into the median (but not dorsal) raphe nucleus in mice exposed to the plus-maze: influence of prior test experienceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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