Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity

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dc.contributor.authorNishimura, Francielli de Cássia Yukari
dc.contributor.authorDe Almeida, Ana Carolina [UNESP]
dc.contributor.authorRatti, Bianca Altrão
dc.contributor.authorUeda-Nakamura, Tânia
dc.contributor.authorNakamura, Celso Vataru
dc.contributor.authorXimenes, Valdecir Farias [UNESP]
dc.contributor.authorDe Oliveira Silva, Sueli
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:11Z
dc.date.available2014-05-27T11:30:11Z
dc.date.issued2013-08-20
dc.description.abstractNaringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils. Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems. With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus. Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils. Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes. The present results challenge the traditional view of antioxidants as improvers of pathological conditions. © 2013 Francielli de Cássia Yukari Nishimura et al.en
dc.description.affiliationDepartamento de Ciências Básicas da Saúde Universidade Estadual de Maringá, Avenida Colombo 5.790, 87020-900 Maringá, PR
dc.description.affiliationDepartamento de Química Faculdade de Ciências Universidade Estadual Paulista, Avenida Eng. Luiz Edmundo Carrijo Coube 14-01, 17033-360 Bauru, SP
dc.description.affiliationUnespDepartamento de Química Faculdade de Ciências Universidade Estadual Paulista, Avenida Eng. Luiz Edmundo Carrijo Coube 14-01, 17033-360 Bauru, SP
dc.identifierhttp://dx.doi.org/10.1155/2013/795916
dc.identifier.citationEvidence-based Complementary and Alternative Medicine, v. 2013.
dc.identifier.doi10.1155/2013/795916
dc.identifier.file2-s2.0-84881505551.pdf
dc.identifier.issn1741-427X
dc.identifier.issn1741-4288
dc.identifier.lattes4066413997908572
dc.identifier.scopus2-s2.0-84881505551
dc.identifier.urihttp://hdl.handle.net/11449/76293
dc.identifier.wosWOS:000322638000001
dc.language.isoeng
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,683
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjecthypochlorous acid
dc.subjectnaringenin
dc.subjectquercetin
dc.subjectreactive oxygen metabolite
dc.subjectantioxidant activity
dc.subjectcontrolled study
dc.subjectflow cytometry
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectmicrobial activity
dc.subjectneutrophil
dc.subjectphagocyte
dc.subjectpriority journal
dc.subjectscanning electron microscopy
dc.subjectStaphylococcus aureus
dc.titleAntioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activityen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/aaa/guidelines/
unesp.author.lattes4066413997908572
unesp.author.orcid0000-0003-2636-3080[6]
unesp.author.orcid0000-0001-5057-3518[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentQuímica - FCpt

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