Streptozotocin: Pharmacology, effectiveness and side effects

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dc.contributor.authorSamuel, Renata O.
dc.contributor.authorAzuma, Mariane M. [UNESP]
dc.contributor.authorSumida, Dóris H. [UNESP]
dc.contributor.authorSivieri-Araújo, Gustavo [UNESP]
dc.contributor.authorJacinto, Rogério de C. [UNESP]
dc.contributor.authorDezan-Júnior, Eloi [UNESP]
dc.contributor.authorGomes-Filho, João E. [UNESP]
dc.contributor.authorCintra, Luciano T.A. [UNESP]
dc.contributor.institutionSchool of Dentistry
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:28:30Z
dc.date.available2019-10-06T15:28:30Z
dc.date.issued2018-07-11
dc.description.abstractStreptozotocin (STZ) is a compound that was originally identified in the late 1950s as an antibiotic, and currently is widely used to induce experimental diabetes mellitus. Its mechanism of action is because STZ enters Beta-cells (β-cells) via the GLUT2 transporter and accumulates intracellularly, being a glucose analogue. Although STZ has been used in research, there is no standardization of a well-established protocol. It's important to highlight that STZ has non-specific toxicity on other organs elicited, which can contribute to variability in its outcomes. In addition, the variability may occur due to the wide range of protocols, including the association of STZ with nicotinamide or hypercaloric diets, variations in the dosage route, drug concentration, lineage and gender of the animal model. Thus, it is necessary to consider the relationship between the induction methodology and the possible pharmacological interactions, evaluating its advantages and disadvantages. This review aims to relate the influence of different protocols of induction of diabetes mellitus with STZ on the effectiveness of the method and possible side effects of this compound.en
dc.description.affiliationDepartament of Clinical Dentistry Uberaba University (Uniube) School of Dentistry
dc.description.affiliationDepartment of Endodontics São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationDepartment of Basic Science São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationUnespDepartment of Endodontics São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationUnespDepartment of Basic Science São Paulo State University (Unesp) School of Dentistry
dc.format.extent145-162
dc.identifier.citationAdvances in Health and Disease, v. 6, p. 145-162.
dc.identifier.lattes3953630077047017
dc.identifier.orcid0000-0002-2362-8920
dc.identifier.scopus2-s2.0-85058906880
dc.identifier.urihttp://hdl.handle.net/11449/187198
dc.language.isoeng
dc.relation.ispartofAdvances in Health and Disease
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnimal model
dc.subjectDiabetes mellitus
dc.subjectStreptozotocin
dc.titleStreptozotocin: Pharmacology, effectiveness and side effectsen
dc.typeCapítulo de livro
unesp.author.lattes3953630077047017[5]
unesp.author.orcid0000-0002-2362-8920[5]

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