Bone formation following implantation of titanium sponge rods into humeral osteotomies in dogs: A histological and histometrical study

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dc.contributor.authorFaria, Paulo Esteves Pinto
dc.contributor.authorCarvalho, Alexandre Leite
dc.contributor.authorFelipucci, Daniela Nair Borges
dc.contributor.authorWen, Cui'e
dc.contributor.authorSennerby, Lars
dc.contributor.authorSalata, Luiz Antonio
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionGeelong Campus
dc.contributor.institutionGothenburg University
dc.date.accessioned2022-04-29T08:44:15Z
dc.date.available2022-04-29T08:44:15Z
dc.date.issued2010-03-01
dc.description.abstractBackground: Titanium (Ti) is widely proven to enhance bone contact and growth on its surface. It is expected that bone defects could benefit from Ti to promote healing and to increase strength of the implanted area. Purpose: The present study aimed at comparing the potential of porous Ti sponge rods with synthetic hydroxyapatite (HA) for the healing of bone defects in a canine model. Material and Methods: Six mongrel dogs were submitted to three trephined osteotomies of 6.0 × 4.0 mm in one humerus and after 2 months another three osteotomies were performed in the contralateral humerus. A total of 36 defects were randomly filled either with Ti foam, particulate HA, or coagulum (control). The six animals were killed 4 months after the first surgery for histological and histometrical analysis. Results: The Ti-foam surface was frequently found in intimate contact with new bone especially at the defect walls. Control sites showed higher amounts of newly formed bone at 2 months - Ti (p = 0.000) and HA (p = 0.009) - and 4 months when compared with Ti (p = 0.001). Differently from HA, the Ti foam was densely distributed across the defect area which rendered less space for bone growth in the latter's sites. The use of Ti foams or HA resulted in similar amounts of bone formation in both time intervals. Nevertheless, the presence of a Ti-foam rod preserved defect's marginal bone height as compared with control groups. Also, the Ti-foam group showed a more mature bone pattern at 4 months than HA sites. Conclusion: The Ti foam exhibited good biocompatibility, and its application resulted in improved maintenance of bone height compared with control sites. The Ti foam in a rod design exhibited bone ingrowth properties suitable for further exploration in other experimental situations. © 2008, Copyright the Authors. Journal Compilation © 2008, Wiley Periodicals, Inc.en
dc.description.affiliationDepartment of Oral and Maxillofacial Surgery Faculty of Dentistry of Araçatuba University of São Paulo, São Paulo
dc.description.affiliationDepartment of Oral and Maxillofacial Surgery and Periodontics Faculty of Dentistry of Ribeirão Preto University of São Paulo, São Paulo
dc.description.affiliationDepartment of Dental Materials and Prosthodontics Faculty of Dentistry of Ribeirão Preto University of São Paulo, São Paulo
dc.description.affiliationDepartment of Engineering and Technology Deakin University Geelong Campus, Geelong, Victoria
dc.description.affiliationDepartment of Biomaterials Sahlgrenska Academy Gothenburg University, Göteborg
dc.description.affiliationDepartment of Oral and Maxillofacial Surgery and Periodontics Faculty of Dentistry of Ribeirão Preto University of São Paulo, Ribeirão Preto
dc.format.extent72-79
dc.identifierhttp://dx.doi.org/10.1111/j.1708-8208.2008.00132.x
dc.identifier.citationClinical Implant Dentistry and Related Research, v. 12, n. 1, p. 72-79, 2010.
dc.identifier.doi10.1111/j.1708-8208.2008.00132.x
dc.identifier.issn1523-0899
dc.identifier.issn1708-8208
dc.identifier.scopus2-s2.0-76549109702
dc.identifier.urihttp://hdl.handle.net/11449/231226
dc.language.isoeng
dc.relation.ispartofClinical Implant Dentistry and Related Research
dc.sourceScopus
dc.subjectBone healing
dc.subjectHydroxyapatite
dc.subjectOsteoconductivity
dc.subjectTitanium scaffold
dc.titleBone formation following implantation of titanium sponge rods into humeral osteotomies in dogs: A histological and histometrical studyen
dc.typeArtigo

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