Long-term histopathologic evaluation of inferior vena cava after modified Greenfield filter implantation: experimental study in sheep

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dc.contributor.authorYoshida, Winston B.
dc.contributor.authorSequera, J. [UNESP]
dc.contributor.authorMaffei, F. H. de Abreu
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBotucatu School of Medicine
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-29T08:44:12Z
dc.date.accessioned2014-05-20T15:21:33Z
dc.date.available2022-04-29T08:44:12Z
dc.date.available2014-05-20T15:21:33Z
dc.date.issued2004-06-01
dc.description.abstractAim. The authors assess a modified Greenfield filter (GF) for the long-term patency, filter tilting and histopathologic alterations of the inferior vena cava (IVC). Methods. Adult sheep (n=7) underwent modified GF placement in the IVC. Cavograms were obtained every 3 months and pulmonary angiography at 12 months. Histopathologic and scanning electron microscopy (SEM) analyses were performed on the IVC explanted at 12 months. Results. Cavograms showed that all IVC were patent at the end of the study. Filter tilting occurred in 2/7 animals and extrusion of struts was not observed. Macroscopic examination at explantation showed minimal venous wall thickening. Microscopic examination showed minimal IVC fibrosis and intimal hyperplasia. SEM showed endothelium on the IVC surface at the filter implantation site and a presumed endothelial layer covering partially or totally the struts. The interface filter-IVC was covered by deposits of leucocytes and platelets. No signs of pulmonary embolism were found in all pulmonary angiograms of both groups. Conclusion. The modified filter presented good biocompatibility, stability and absence of thrombogenicity at 12 months. It presented low tendency to tilting and extrusion of struts. The long-term histopathologic alterations in vena caval wall were minimal and the appearance of the studied filters in the IVC was similar to stents placed in the arterial system.en
dc.description.affiliationDepartment of Surgery/Orthopedics Botucatu School of Medicine, 18618-970 Botucatu, São Paulo
dc.description.affiliationDepartment of Pathology School of Veterinary Medicine Paulista State University, São Paulo
dc.description.affiliationBotucatu Sch Med, Dept Surg & Orthopedt, Botucadu, SP, Brazil
dc.description.affiliationPaulista State Univ, Dept Pathol, Sch Vet Med, São Paulo, Brazil
dc.description.affiliationUnespDepartment of Pathology School of Veterinary Medicine Paulista State University, São Paulo
dc.description.affiliationUnespPaulista State Univ, Dept Pathol, Sch Vet Med, São Paulo, Brazil
dc.format.extent170-176
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15507896
dc.identifier.citationInternational Angiology, v. 23, n. 2, p. 170-176, 2004.
dc.identifier.citationInternational Angiology. Turin: Edizioni Minerva Medica, v. 23, n. 2, p. 170-176, 2004.
dc.identifier.issn0392-9590
dc.identifier.lattes3409765424060945
dc.identifier.scopus2-s2.0-7044223232
dc.identifier.urihttp://hdl.handle.net/11449/243878
dc.identifier.wosWOS:000224800300013
dc.language.isoeng
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofInternational Angiology
dc.relation.ispartofjcr1.156
dc.relation.ispartofsjr0,476
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.sourceWeb of Science
dc.subjectFilteren
dc.subjectPulmonary embolismen
dc.subjectVena cava, inferioren
dc.titleLong-term histopathologic evaluation of inferior vena cava after modified Greenfield filter implantation: experimental study in sheepen
dc.typeArtigo
dcterms.rightsHolderEdizioni Minerva Medica
unesp.author.lattes3409765424060945

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