Ethyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creams

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dc.contributor.authorNazare, Ana C. [UNESP]
dc.contributor.authorFaria, Carolina M. Q. G. de [UNESP]
dc.contributor.authorChiari, Bruna G. [UNESP]
dc.contributor.authorPetronio, Maicon S. [UNESP]
dc.contributor.authorRegasini, Luis O. [UNESP]
dc.contributor.authorSilva, Dulce Helena Siqueira [UNESP]
dc.contributor.authorCorrea, Marcos A. [UNESP]
dc.contributor.authorIsaac, Vera L. B. [UNESP]
dc.contributor.authorFonseca, Luiz M. da [UNESP]
dc.contributor.authorXimenes, Valdecir F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:42Z
dc.date.available2014-12-03T13:11:42Z
dc.date.issued2014-06-01
dc.description.abstractEthyl ferulate (FAEE) has been widely studied due to its beneficial heath properties and, when incorporated in creams, shows a high sun protection capacity. Here we aimed to compare FAEE and its precursor, ferulic acid (FA), as free radical scavengers, inhibitors of oxidants produced by leukocytes and the alterations in rheological properties when incorporated in emulsion based creams. The cell-free antiradical capacity of FAEE was decreased compared to FA. However, FAEE was more effective regarding the scavenging of reactive oxygen species produced by activated leukocytes. Stress and frequency sweep tests showed that the formulations are more elastic than viscous. The viscoelastic features of the formulations were confirmed in the creep and recovery assay and showed that the FAEE formulation was less susceptive to deformation. Liberation experiments showed that the rate of FAEE release from the emulsion was slower compared to FA. In conclusion, FAEE is more effective than FA as a potential inhibitor of oxidative damage produced by oxidants generated by leukocytes. The rheological alterations caused by the addition of FAEE are indicative of lower spreadability, which could be useful for formulations used in restricted areas of the skin.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Cosmetol, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ,Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Quim, Fac Ciencias, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Cosmetol, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ,Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Quim, Fac Ciencias, BR-17033360 Bauru, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent8124-8139
dc.identifierhttp://dx.doi.org/10.3390/molecules19068124
dc.identifier.citationMolecules. Basel: Mdpi Ag, v. 19, n. 6, p. 8124-8139, 2014.
dc.identifier.doi10.3390/molecules19068124
dc.identifier.fileWOS000338586700074.pdf
dc.identifier.issn1420-3049
dc.identifier.lattes4702004904231248
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.urihttp://hdl.handle.net/11449/113440
dc.identifier.wosWOS:000338586700074
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofMolecules
dc.relation.ispartofjcr3.098
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectneutrophilen
dc.subjectNADPH oxidaseen
dc.subjectoxidative stressen
dc.subjectferulic aciden
dc.subjectethyl ferulateen
dc.subjectcosmetic producten
dc.titleEthyl Ferulate, a Component with Anti-Inflammatory Properties for Emulsion-Based Creamsen
dc.typeArtigo
dcterms.rightsHolderMdpi Ag
unesp.author.lattes4702004904231248[6]
unesp.author.orcid0000-0002-1516-7765[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentQuímica - FCpt

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Artigos - Análises Clínicas - FCFAR
Artigos - Química Orgânica - IQ
Bauru - FC - Faculdade de Ciências