Exposure to aluminium chloride during the peripuberal period induces prostate damage in male rats

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dc.contributor.authorLeal, Franciely A.V.D.
dc.contributor.authorGonçalves, Gessica D.
dc.contributor.authorSoncini, João Gabriel M.
dc.contributor.authorStaurengo-Ferrari, Larissa
dc.contributor.authorFattori, Victor
dc.contributor.authorVerri Jr, Waldiceu A.
dc.contributor.authorScarano, Wellerson R. [UNESP]
dc.contributor.authorFernandes, Glaura S.A.
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:49:08Z
dc.date.available2022-04-28T19:49:08Z
dc.date.issued2022-01-01
dc.description.abstractAluminium (Al) is an important metal, but it can be toxic including for prostate tissue. This study aimed to evaluate whether exposure to aluminium chloride (AlCl3) during the peripubertal period affects ventral prostate development in rats. Male Wistar rats (30 days old) were distributed into three experimental groups: control (sterile 0.9% saline solution), AL7 (7 mg AlCl3/kg) and AL34 (34 mg AlCl3/kg). Animals were treated intraperitoneally from postnatal day (PND) 36–66 (peripubertal period). At PND67, the animals were anaesthetized and euthanized. Blood was collected for testosterone levels. The ventral prostate (VP) was removed, weighed and processed for histochemistry and immunohistochemistry to detect androgen (AR) and Ki67. Stereological and histopathological analyses, mast cell counts, and determinations of myeloperoxidase (MPO) and N-acetyl glycosidase (NAG) activity and IL-6 levels were performed. The AL34 group presented a reduction in body weight and increase in MPO activity compared to the other groups. In both the AL7 and AL34 groups, there was reorganization of the prostatic tissue compartments. There was no significant difference in prostate weight, number of granulated or degranulated mast cells, or testosterone levels. In conclusion, the exposure to aluminium chloride during the peripubertal period impairs the prostatic development.en
dc.description.affiliationDepartment of General Biology Biological Sciences Center State University of Londrina – UEL, Paraná
dc.description.affiliationDepartment of Pathological Sciences Biological Sciences Center State University of Londrina – UEL, Paraná
dc.description.affiliationDepartment of Morphology Institute of Biosciences UNESP — Univ Estadual Paulista, SP
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences UNESP — Univ Estadual Paulista, SP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 406189/2016-1
dc.identifierhttp://dx.doi.org/10.1016/j.acthis.2022.151843
dc.identifier.citationActa Histochemica, v. 124, n. 1, 2022.
dc.identifier.doi10.1016/j.acthis.2022.151843
dc.identifier.issn1618-0372
dc.identifier.issn0065-1281
dc.identifier.scopus2-s2.0-85122457937
dc.identifier.urihttp://hdl.handle.net/11449/223192
dc.language.isoeng
dc.relation.ispartofActa Histochemica
dc.sourceScopus
dc.subjectAluminium chloride
dc.subjectInflammation
dc.subjectTestosterone
dc.subjectVentral prostate
dc.titleExposure to aluminium chloride during the peripuberal period induces prostate damage in male ratsen
dc.typeArtigo

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