Serum homocysteine and physical exercise in patients with Parkinson's disease

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dc.contributor.authorCrispim Nascimento, Carla Manuela [UNESP]
dc.contributor.authorStella, Florindo [UNESP]
dc.contributor.authorGarlipp, Celia Regina
dc.contributor.authorSantos, Ruth Ferreira [UNESP]
dc.contributor.authorGobbi, Sebastiao [UNESP]
dc.contributor.authorBucken Gobbi, Lilian Teresa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2013-09-30T18:49:07Z
dc.date.accessioned2014-05-20T13:58:41Z
dc.date.available2013-09-30T18:49:07Z
dc.date.available2014-05-20T13:58:41Z
dc.date.issued2011-06-01
dc.description.abstractBackground: Hyperhomocysteinemia is a major risk factor for cerebral and peripheral vascular diseases, as well as cortical and hippocampal injury, including an increased risk of dementia and cognitive impairment. Elevated serum homocysteine (Hcy) concentrations are common in patients with Parkinson's disease (PD) who have been treated with levodopa; however, physical exercises can help reduce Hcy concentrations. The aim of the present study was to compare serum Hcy levels in patients with PD who partook in regular physical exercises, sedentary PD patients, and healthy controls.Methods: Sixty individuals were enrolled in the present study across three groups: (i) 17 patients who did not partake of any type of exercise; (ii) 24 PD patients who exercised regularly; and (iii) 19 healthy individuals who did not exercise regularly. All participants were evaluated by Hoehn and Yahr scale, the Unified Parkinson's Disease Rating Scale (UPDRS) and Schwab and England scale (measure daily functionality). The serum levels of Hcy were analyzed by blood samples collected of each participant. An analysis of variance and a Tukey's post hoc test were applied to compare and to verify differences between groups. Pearson's correlation and stepwise multiple regression analyses were used to consider the association between several variables.Results: Mean plasma Hcy concentrations in individuals who exercised regularly were similar to those in the healthy controls and significantly lower than those in the group that did not exercise at all (P = 0.000). In addition, patients who did not exercise were receiving significantly higher doses of levodopa than those patients who exercised regularly (P = 0.001). A positive relationship between levodopa dose and Hcy concentrations (R(2) = 0.27; P = 0.03) was observed in patients who did not exercise, but not in those patients who exercised regularly (R(2) = 0.023; P = 0.15).Conclusions: The results of the present study suggest that, even with regular levodopa therapy, Hcy concentrations in PD patients who exercise regularly are significantly lower than in patients who do not exercise and are similar Hcy concentrations in healthy controls.en
dc.description.affiliationSão Paulo State Univ, Dept Phys Educ, Biosci Inst, Lab Aging & Phys Act LAFE, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Med Sci, Clin Pathol Lab, Campinas, SP, Brazil
dc.description.affiliationFed Univ ABC, Math Computat & Cognit Ctr, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Phys Educ, Biosci Inst, Lab Posture & Locomot Study LEPLO, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Phys Educ, Biosci Inst, Lab Aging & Phys Act LAFE, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Phys Educ, Biosci Inst, Lab Posture & Locomot Study LEPLO, São Paulo, Brazil
dc.format.extent105-112
dc.identifierhttp://dx.doi.org/10.1111/j.1479-8301.2011.00356.x
dc.identifier.citationPsychogeriatrics. Malden: Wiley-blackwell, v. 11, n. 2, p. 105-112, 2011.
dc.identifier.doi10.1111/j.1479-8301.2011.00356.x
dc.identifier.issn1346-3500
dc.identifier.lattes7964386240653380
dc.identifier.lattes9868835271822421
dc.identifier.urihttp://hdl.handle.net/11449/20851
dc.identifier.wosWOS:000292269900005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofPsychogeriatrics
dc.relation.ispartofjcr1.209
dc.relation.ispartofsjr0,459
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjecthomocysteineen
dc.subjectParkinson's diseaseen
dc.subjectphysical exerciseen
dc.titleSerum homocysteine and physical exercise in patients with Parkinson's diseaseen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes7964386240653380
unesp.author.lattes9868835271822421
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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