Polymorphisms in risk genes of type 2 diabetes mellitus could be also markers of susceptibility to periodontitis

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dc.contributor.authorSilva, Arles Naisa Amaral [UNESP]
dc.contributor.authorNicchio, Ingra Gagno [UNESP]
dc.contributor.authorda Silva, Bárbara Roque [UNESP]
dc.contributor.authorMartelli, Maurício Gandini Giani [UNESP]
dc.contributor.authorHidalgo, Marco A. Rimachi [UNESP]
dc.contributor.authorNepomuceno, Rafael [UNESP]
dc.contributor.authorTheodoro, Letícia H. [UNESP]
dc.contributor.authorCirelli, Joni A. [UNESP]
dc.contributor.authorOrrico, Silvana R.P. [UNESP]
dc.contributor.authorCirelli, Thamiris [UNESP]
dc.contributor.authorBarros, Silvana P.
dc.contributor.authorScarel-Caminaga, Raquel M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUnion of the Colleges of the Great Lakes (UNILAGO)
dc.contributor.institutionUniversity Center of the Associated Faculties
dc.contributor.institutionUniversity of North Carolina at Chapel Hill - UNC
dc.date.accessioned2023-03-01T21:11:03Z
dc.date.available2023-03-01T21:11:03Z
dc.date.issued2022-11-01
dc.description.abstractObjectives: This study aimed to investigate polymorphisms in genes considered molecular biomarkers of type 2 diabetes mellitus (T2DM) to assess whether they are associated with periodontitis, and relating them to the periodontal status, glycemic and lipid profile of the subjects. Design: We investigated individuals who underwent complete periodontal examination and biochemical evaluation. We categorized them into three groups: (i) periodontitis with T2DM (Periodontitis+T2DM group, n = 206); (ii) periodontitis without T2DM (Periodontitis group, n = 346); and (iii) healthy individuals without Periodontitis or T2DM (Healthy group, n = 345). We investigated three single nucleotide polymorphisms (SNPs) for AGER, RBMS1 and VEGFA genes. We applied multivariate logistic and multiple linear regression models for all groups and stratified the subjects by sex and smoking habits. Results: Compared with RBMS1-rs7593730-CC+CT genotype carriers, RBMS1-rs7593730-TT carriers were more susceptible to periodontitis [odds ratio (OR) = 2.29; 95% confidence interval (CI) = 1.04–5.01; P-value = 0.033]. Among AGER-rs184003-CC carriers, never smokers had reduced risks of periodontitis and Periodontitis+T2DM than ever smokers. For either RBMS1-rs7593730-CC or VEGFA-rs9472138-CC carriers, never smokers had less susceptibility to develop periodontitis than ever smokers. Compared with AGER-rs184003-CC carriers, AGER-rs184003-AA carriers presented fewer remaining teeth. VEGFA-rs9472138-TT carriers showed a lower percentage of sites with characteristics of active periodontal disease (bleeding on pocket probing and interproximal clinical attachment level) compared with VEGFA-rs9472138-CC carriers. Conclusions: In the studied population, AGER rs184003, RBMS1 rs7593730, and VEGFA rs9472138, which are considered genetic markers for T2DM, were associated with periodontitis without T2DM or periodontitis together with T2DM.en
dc.description.affiliationDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araraquara, SP
dc.description.affiliationDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara São Paulo State University - UNESP, SP
dc.description.affiliationDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araçatuba, SP
dc.description.affiliationAdvanced Research Center in Medicine Union of the Colleges of the Great Lakes (UNILAGO), SP
dc.description.affiliationDepartment of Dentistry University Center of the Associated Faculties, SP
dc.description.affiliationDepartment of Comprehensive Oral Health - Periodontology School of Dentistry University of North Carolina at Chapel Hill - UNC
dc.description.affiliationUnespDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araraquara, SP
dc.description.affiliationUnespDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara São Paulo State University - UNESP, SP
dc.description.affiliationUnespDepartment of Diagnosis and Surgery São Paulo State University – UNESP School of Dentistry at Araçatuba, SP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2014/13295-1
dc.description.sponsorshipIdFAPESP: 2016/03753-8
dc.description.sponsorshipIdFAPESP: 2016/08070-6
dc.description.sponsorshipIdFAPESP: 2016/18313-3
dc.description.sponsorshipIdCNPq: 304570/2017-6
dc.description.sponsorshipIdCNPq: 306073/2020-0
dc.description.sponsorshipIdCNPq: 445336/2014-5
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2022.105529
dc.identifier.citationArchives of Oral Biology, v. 143.
dc.identifier.doi10.1016/j.archoralbio.2022.105529
dc.identifier.issn1879-1506
dc.identifier.issn0003-9969
dc.identifier.scopus2-s2.0-85137016255
dc.identifier.urihttp://hdl.handle.net/11449/241576
dc.language.isoeng
dc.relation.ispartofArchives of Oral Biology
dc.sourceScopus
dc.subjectBiomarker
dc.subjectDiabetes mellitus
dc.subjectGenetic
dc.subjectGWAS
dc.subjectPeriodontitis
dc.subjectPolymorphism
dc.titlePolymorphisms in risk genes of type 2 diabetes mellitus could be also markers of susceptibility to periodontitisen
dc.typeArtigo

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