Systemic effect of mineral aggregate based cements: histopathological analysis in rats

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dc.contributor.authorRoberti Garcia, Lucas da Fonseca
dc.contributor.authorHuck, Claudia [UNESP]
dc.contributor.authorCintra Magalhaes, Fernando Augusto [UNESP]
dc.contributor.authorChaves de Souza, Pedro Paulo [UNESP]
dc.contributor.authorSouza Costa, Carlos Alberto de [UNESP]
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:42:34Z
dc.date.available2018-11-26T17:42:34Z
dc.date.issued2017-11-01
dc.description.abstractObjective: Several studies reported the local tissue reaction caused by mineral aggregate-based cements. However, few studies have investigated the systemic effects promoted by these cements on liver and kidney when directly applied to connective tissue. The purpose of this in vivo study was to investigate the systemic effect of mineral aggregate-based cements on the livers and kidneys of rats. Material and Methods: Samples of Mineral Trioxide Aggregate (MTA) and a calcium aluminate-based cement (EndoBinder) containing different radiopacifiers were implanted into the dorsum of 40 rats. After 7 and 30 d, samples of subcutaneous, liver and kidney tissues were submitted to histopathological analysis. A score (0-3) was used to grade the inflammatory reaction. Blood samples were collected to evaluate changes in hepatic and renal functions of animals. Results: The moderate inflammatory reaction (2) observed for 7 d in the subcutaneous tissue decreased with time for all cements. The thickness of inflammatory capsules also presented a significant decrease with time (P<.05). Systemically, all cements caused adverse inflammatory reactions in the liver and kidney, being more evident for MTA, persisting until the end of the analysis. Liver functions increased significantly for MTA during 30 d (P<.05). Conclusion: The different cements induced to a locally limited inflammatory reaction. However, from the systemic point of view, the cements promoted significant inflammatory reactions in the liver and kidney. For MTA, the reactions were more accentuated.en
dc.description.affiliationUniv Fed Santa Catarina, Ctr Ciencias Saude, Dept Odontol, Area Endodontia, Florianopolis, SC, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Odontol Araraquara, Dept Odontol Restauradora, Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Odontol Araraquara, Dept Fisiol & Patol, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol Araraquara, Dept Odontol Restauradora, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol Araraquara, Dept Fisiol & Patol, Araraquara, SP, Brazil
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 443153/2014-0
dc.description.sponsorshipIdCNPq: 303599/2014-6
dc.format.extent620-630
dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2016-0634
dc.identifier.citationJournal Of Applied Oral Science. Bauru-sp: Univ Sao Paulo Fac Odontologia Bauru, v. 25, n. 6, p. 620-630, 2017.
dc.identifier.doi10.1590/1678-7757-2016-0634
dc.identifier.fileS1678-77572017000600620.pdf
dc.identifier.issn1678-7757
dc.identifier.scieloS1678-77572017000600620
dc.identifier.urihttp://hdl.handle.net/11449/163570
dc.identifier.wosWOS:000417175900006
dc.language.isoeng
dc.publisherUniv Sao Paulo Fac Odontologia Bauru
dc.relation.ispartofJournal Of Applied Oral Science
dc.relation.ispartofsjr0,645
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectEndodontics
dc.subjectBiocompatible materials
dc.subjectInflammation
dc.subjectLiver
dc.subjectKidney
dc.titleSystemic effect of mineral aggregate based cements: histopathological analysis in ratsen
dc.typeArtigo
dcterms.rightsHolderUniv Sao Paulo Fac Odontologia Bauru
unesp.author.lattes4517484241515548[5]
unesp.author.orcid0000-0002-7455-6867[5]

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Artigos - Odontologia Restauradora - FOAR
Artigos - Fisiologia e Patologia - FOAR