SUPEROXIDE RADICAL AND TOXICITY OF ENVIRONMENTAL NICKEL EXPOSURE

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dc.contributor.authorNovelli, ELB
dc.contributor.authorRodrigues, N. L.
dc.contributor.authorRibas, B. O.
dc.contributor.institutionINST SALUD CARLOS 3
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:26:29Z
dc.date.available2014-05-20T15:26:29Z
dc.date.issued1995-03-01
dc.description.abstractThree nickel compounds were tested for pancreatic, hepatic and osteogenic damage in rats by a single i.m. injection Ni++ (7 mg kg(-1)). The nickel induced biochemical alterations included significantly increased levels of serum alkaline phosphatase in rats with NiS (75%) and NiO (50%). Amylase and aspartate transaminase were also increased, and lipoperoxide was increased in rats with NiO (5.6-fold) and NiS (3.4-fold). No serum changes were observed with NiCl2. Daily injection of Cu-Zn superoxide dismutase (SOD) conjugated with polyethylene glycol prevented the serum level changes, indicating that superoxide radical is an important intermediate in toxicity of nickel insoluble compounds.en
dc.description.affiliationINST SALUD CARLOS 3,MINIST SANIDAD & CONSUMO,MADRID,SPAIN
dc.format.extent248-251
dc.identifierhttp://dx.doi.org/10.1177/096032719501400303
dc.identifier.citationHuman & Experimental Toxicology. Basingstoke: Stockton Press, v. 14, n. 3, p. 248-251, 1995.
dc.identifier.doi10.1177/096032719501400303
dc.identifier.issn0144-5952
dc.identifier.urihttp://hdl.handle.net/11449/36647
dc.identifier.wosWOS:A1995QQ39500004
dc.language.isoeng
dc.publisherStockton Press
dc.relation.ispartofHuman & Experimental Toxicology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectNICKELpt
dc.subjectSUPEROXIDE RADICALpt
dc.subjectTOXICITYpt
dc.subjectSUPEROXIDE DISMUTASEpt
dc.subjectRATSpt
dc.titleSUPEROXIDE RADICAL AND TOXICITY OF ENVIRONMENTAL NICKEL EXPOSUREen
dc.typeArtigo
dcterms.licensehttp://www.sagepub.com/authors/journal/permissions.sp#7
dcterms.rightsHolderStockton Press

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