Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes

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dc.contributor.authorSouza, José António Santos [UNESP]
dc.contributor.authorAlves, Marta M.
dc.contributor.authorBarbosa, Debora Barros [UNESP]
dc.contributor.authorLopes, Maria Manuel
dc.contributor.authorPinto, Eugénia
dc.contributor.authorFigueiral, Maria Helena
dc.contributor.authorDelbem, Alberto Carlos B [UNESP]
dc.contributor.authorMira, Nuno Pereira
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Lisboa
dc.contributor.institutionFaculdade de Farmácia da Universidade de Lisboa
dc.contributor.institutionTerminal de Cruzeiros do Porto de Leixões
dc.contributor.institutionPorto University
dc.date.accessioned2020-12-12T02:09:26Z
dc.date.available2020-12-12T02:09:26Z
dc.date.issued2020-06-01
dc.description.abstractThe continuous emergence of Candida strains resistant to currently used antifungals demands the development of new alternatives that could reduce the burden of candidiasis. In this work silver nanoparticles synthesized using a green route are efficiently used, alone or in combination with fluconazole, amphotericin B or nystatine, to inhibit growth of C. albicans and C. glabrata oral clinical strains, including in strains showing resistance to fluconazole. A potent inhibitory effect over biofilm formation prompted by the two Candida species was also observed, including in mature biofilm cells. These results foster the use of phytotherapeutics as effective treatments in oral candidiasis.en
dc.description.affiliationSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Pediatric Dentistry and Public Health
dc.description.affiliationCentro de Química Estrutural Instituto Superior Técnico Universidade de Lisboa
dc.description.affiliationSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Dental Materials and Prosthodontics
dc.description.affiliationFaculdade de Farmácia da Universidade de Lisboa Departamento de Microbiologia e Imunologia, Av. Prof. Gama Pinto
dc.description.affiliationLaboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy of University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
dc.description.affiliationInterdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR) University of Porto Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos
dc.description.affiliationFaculty of Dentistry Porto University, Rua Manuel Pereira da Silva
dc.description.affiliationiBB, Institute for Bioengineering and Biosciences, Instituto Superior Técnico - Department of Bioengineering, Universidade de Lisboa, Lisbon, Portugal
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Pediatric Dentistry and Public Health
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Dental Materials and Prosthodontics
dc.format.extent564-567
dc.identifierhttp://dx.doi.org/10.1093/mmy/myz094
dc.identifier.citationMedical mycology, v. 58, n. 4, p. 564-567, 2020.
dc.identifier.doi10.1093/mmy/myz094
dc.identifier.issn1460-2709
dc.identifier.scopus2-s2.0-85085714953
dc.identifier.urihttp://hdl.handle.net/11449/200544
dc.language.isoeng
dc.relation.ispartofMedical mycology
dc.sourceScopus
dc.subjectPunica granatum
dc.subjectoral candidiasis
dc.subjectphytotherapeutics
dc.subjectsilver nanoparticles
dc.subject‘green’ synthesis
dc.titleStudy of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenesen
dc.typeArtigo

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Artigos - Odontologia Infantil e Social - FOA
Artigos - Materiais Odontológicos e Prótese - FOA