Polyhydroxyalkanoates: Naturally occurring microbial polymers suitable for nanotechnology applications

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dc.contributor.authorDe Paula-Elias, Fabrício C.
dc.contributor.authorDe Paula, Carolina B. C. [UNESP]
dc.contributor.authorDe Oliveira, Nayra M. L.
dc.contributor.authorDe Almeida, Alex F.
dc.contributor.authorContiero, Jonas [UNESP]
dc.contributor.institutionFederal University of Tocantins
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-05-01T16:48:26Z
dc.date.available2022-05-01T16:48:26Z
dc.date.issued2021-01-01
dc.description.abstractPolyhydroxyalkanoates (PHAs) are intracellular microbial polyesters synthesized by many species of Bacteria and Archaea, generally under nutrient limitation and excess of carbon source as storage granules of energy and also conferring stress resistance to prokaryotes. PHAs are naturally occurring, and the choice of microbial strains and carbon sources for cell cultivations results in biopolymers with different physicochemical properties. Cupriavidus necator is a bacterial strain able to synthesize a high crystalline polymer, poly(3-hydroxybutyrate), the most common of all PHAs; whereas Pseudomonas species produce PHAs with medium chain-length monomers, which exhibit elastomeric properties as natural rubbers. This variety of monomer composition associated with high biocompatibility and biodegradability makes PHAs also feasible for compostable applications and meet the standard specification for marine degradability. Due to their high versatility as natural chemicals and their ecologically friendly properties, PHAs have drawn attention for a wide range of applications from which the PHA nanocomposites have become a promising alternative to petrochemical polymers for nanoscale applications, especially those involved in biomedical materials. This review chapter introduces PHAs from their microbial synthesis, polymer structure to recent applications, with special focus on nanoscience applications. PHA as scaffolds for tissue engineering, nanofibers and particles for catalyst immobilization and drug delivery systems are topics addressed in this chapter. Finally, the future prospects and economical challenges to be overcome by the PHA industry are discussed in this review chapter from a green chemistry background.en
dc.description.affiliationFederal University of Tocantins, Palmas Campus
dc.description.affiliationInstitute of Bioenergy Research São Paulo State University, São Paulo
dc.description.affiliationFederal University of Tocantins, Gurupi Campus
dc.description.affiliationInstitute of Biosciences São Paulo State University, São Paulo
dc.description.affiliationUnespInstitute of Bioenergy Research São Paulo State University, São Paulo
dc.description.affiliationUnespInstitute of Biosciences São Paulo State University, São Paulo
dc.format.extent3-20
dc.identifierhttp://dx.doi.org/10.1016/B978-0-12-822446-5.00001-0
dc.identifier.citationHandbook of Greener Synthesis of Nanomaterials and Compounds: Volume 2: Synthesis at the Macroscale and Nanoscale, p. 3-20.
dc.identifier.doi10.1016/B978-0-12-822446-5.00001-0
dc.identifier.scopus2-s2.0-85127644514
dc.identifier.urihttp://hdl.handle.net/11449/234357
dc.language.isoeng
dc.relation.ispartofHandbook of Greener Synthesis of Nanomaterials and Compounds: Volume 2: Synthesis at the Macroscale and Nanoscale
dc.sourceScopus
dc.subjectBioplastics
dc.subjectDrug delivery system
dc.subjectEnzyme immobilization
dc.subjectNanotechnology
dc.subjectPolyhydroxyalkanoate
dc.subjectTissue engineering
dc.titlePolyhydroxyalkanoates: Naturally occurring microbial polymers suitable for nanotechnology applicationsen
dc.typeCapítulo de livro

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Artigos - Bioquímica e Microbiologia - IBRC