Chromosome aberrations as a predictor of clinical outcome for smoking associated lung cancer

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dc.contributor.authorEl-Zein, R.
dc.contributor.authorAbdel-Rahman, S. Z.
dc.contributor.authorConforti-Froes, N.
dc.contributor.authorAlpard, S. K.
dc.contributor.authorZwischenberger, J. B.
dc.contributor.institutionUniv Texas
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:30:05Z
dc.date.available2014-05-20T15:30:05Z
dc.date.issued2000-09-29
dc.description.abstractThe ability to identify individuals at greatest risk of developing lung cancer can significantly enhance the efficacy of intervention modalities. One strategy for identifying these individuals is through biomarkers that reflect the severity of their cancer. In the present study, we evaluated 22 lung cancer patients and 35 controls to determine whether the frequency of chromosome aberrations was significantly associated with specific clinical variables such as the histological type, grade and stage of the turners. Chromosome aberrations (expressed as total breaks) were investigated on chromosome 1 in interphase nuclei obtained from blood Lymphocytes of the study participants using the fluorescence in situ hybridization (FISH) chromosome aberration assay. Our results indicate a significant linear increase (P = 0.01) in the level of breaks with respect to the grade of the carcinoma. The poorly differentiated tumors had a significantly higher level of chromosome breaks mean +/- SD (1.7 +/- 0.46) as compared to the well differentiated tumors (0.98 +/- 0,23, P < 0,05). These results indicate that chromosome aberrations, as determined by the FISH assay, can be used as a biomarker for identifying individuals with aggressive types of lung cancer and potentially, as a predictor for prognostic outcome of the disease. (C) 2000 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
dc.description.affiliationUniv Texas, Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX 77550 USA
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Sao Jose do Rio Preto, Brazil
dc.description.affiliationUniv Texas, Med Branch, Dept Surg, Galveston, TX 77550 USA
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Sao Jose do Rio Preto, Brazil
dc.format.extent65-71
dc.identifierhttp://dx.doi.org/10.1016/S0304-3835(00)00503-6
dc.identifier.citationCancer Letters. Clare: Elsevier Sci Ireland Ltd, v. 158, n. 1, p. 65-71, 2000.
dc.identifier.doi10.1016/S0304-3835(00)00503-6
dc.identifier.issn0304-3835
dc.identifier.urihttp://hdl.handle.net/11449/39537
dc.identifier.wosWOS:000166662900010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCancer Letters
dc.relation.ispartofjcr6.491
dc.relation.ispartofsjr2,350
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectlung cancerpt
dc.subjectstagespt
dc.subjectgradespt
dc.subjectsmokingpt
dc.subjecthistoplathologypt
dc.subjectchromosome aberrationspt
dc.subjectfluorescence in situ hybridizationpt
dc.titleChromosome aberrations as a predictor of clinical outcome for smoking associated lung canceren
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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