Cardiorespiratory, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anaesthesia

Página do item simplificado
dc.contributor.authorLuna, Stélio Pacca Loureiro [UNESP]
dc.contributor.authorTaylor, P. M.
dc.contributor.authorWheeler, M. J.
dc.contributor.institutionAnimal Health Trust
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionDept. of Clin. Veterinary Medicine
dc.contributor.institutionSt. Thomas's Hospital
dc.date.accessioned2014-05-27T11:18:06Z
dc.date.available2014-05-27T11:18:06Z
dc.date.issued1996-08-21
dc.description.abstractSix Welsh gelding ponies (weight 246 ± 6 kg) were premedicated with 0.03 mg/kg of acepromazine intravenously (i.v.) followed by 0.02 mg/kg of detomidine i.v. Anaesthesia was induced with 2 mg/kg of ketamine i.v. Ponies were intubated and lay in left lateral recumbency. On one occasion anaesthesia was maintained for 2 h using 1.2% halothane in oxygen. The same group of ponies were anaesthetized 1 month later using the same induction regime and anaesthesia was maintained with a combination of detomidine, ketamine and guaiphenesin, while the ponies breathed oxygen-enriched air. Electrocardiogram, heart rate, mean arterial blood pressure, cardiac output, respiratory rate, blood gases, temperature, haematocrit, glucose, lactate and cortisol were measured and cardiac index and systemic vascular resistance were calculated in both groups. Beta-endorphin, met-enkephalin, dynorphin, arginine vasopressin (AVP), adrenocorticotrophic hormone (ACTH) and catecholamines were measured in the halothane anaesthesia group only and 11-deoxycortisol during total intravenous anaesthesia (TIVA) only. Cardiorespiratory depression was more marked during halothane anaesthesia. Hyperglycaemia developed in both groups. Lactate and AVP increased during halothane anaesthesia. Cortisol increased during halothane and decreased during TIVA. There were no changes in the other hormones during anaesthesia. Recovery was smooth in both groups. TIVA produced better cardiorespiratory performance and suppressed the endocrine stress response observed during halothane anaesthesia.en
dc.description.affiliationAnimal Health Trust, Newmarket
dc.description.affiliationFMVZ UNESP Dept. of Vet. Surg. and Anaesthiol., 18618-000, Botucatu, SP
dc.description.affiliationUniversity of Cambridge Dept. of Clin. Veterinary Medicine, Madingley Road, Cambridge CB3 0ES
dc.description.affiliationDept. Endocrinol. and Chem. Pathol. St. Thomas's Hospital, London SE1 7EH
dc.description.affiliationUnespFMVZ UNESP Dept. of Vet. Surg. and Anaesthiol., 18618-000, Botucatu, SP
dc.format.extent251-258
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2885.1996.tb00046.x
dc.identifier.citationJournal of Veterinary Pharmacology and Therapeutics, v. 19, n. 4, p. 251-258, 1996.
dc.identifier.doi10.1111/j.1365-2885.1996.tb00046.x
dc.identifier.issn0140-7783
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.scopus2-s2.0-0029775896
dc.identifier.urihttp://hdl.handle.net/11449/64830
dc.language.isoeng
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.ispartofjcr1.441
dc.relation.ispartofsjr0,700
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectacepromazine
dc.subjectargipressin
dc.subjectbeta endorphin
dc.subjectcatecholamine
dc.subjectcorticotropin
dc.subjectcortodoxone
dc.subjectdetomidine
dc.subjectdynorphin
dc.subjectglucose
dc.subjectguaifenesin
dc.subjecthalothane
dc.subjecthydrocortisone
dc.subjectinhalation anesthetic agent
dc.subjectintravenous anesthetic agent
dc.subjectketamine
dc.subjectlactic acid
dc.subjectmetenkephalin
dc.subjectanesthetic recovery
dc.subjectanimal experiment
dc.subjectblood gas
dc.subjectbody temperature
dc.subjectbreathing rate
dc.subjectcardiovascular system
dc.subjectcontrolled study
dc.subjectelectrocardiogram
dc.subjectendocrine system
dc.subjectheart index
dc.subjectheart output
dc.subjectheart rate
dc.subjecthematocrit
dc.subjecthorse
dc.subjectinhalation anesthesia
dc.subjectinhalational drug administration
dc.subjectintravenous anesthesia
dc.subjectintravenous drug administration
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectmetabolism
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrespiratory function
dc.subjectstress
dc.subjectvascular resistance
dc.subjectveterinary medicine
dc.subjectAcepromazine
dc.subjectAdrenocorticotropic Hormone
dc.subjectAnalgesics
dc.subjectAnalysis of Variance
dc.subjectAnesthesia, Inhalation
dc.subjectAnesthesia, Intravenous
dc.subjectAnesthetics, Dissociative
dc.subjectAnimals
dc.subjectArginine Vasopressin
dc.subjectBlood Gas Analysis
dc.subjectBlood Glucose
dc.subjectBlood Pressure
dc.subjectBody Temperature
dc.subjectCardiac Output
dc.subjectCatecholamines
dc.subjectDopamine Antagonists
dc.subjectElectrocardiography
dc.subjectEndorphins
dc.subjectHalothane
dc.subjectHeart Rate
dc.subjectHematocrit
dc.subjectHorses
dc.subjectHydrocortisone
dc.subjectImidazoles
dc.subjectKetamine
dc.subjectLactic Acid
dc.titleCardiorespiratory, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anaesthesiaen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0001-5312-9076[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

Arquivos

Coleções

Artigos - Cirurgia e Anestesiologia Veterinária - FMVZ