Multilevel assessment of chlorothalonil sediment toxicity to Latin American estuarine biota: Effects on biomarkers, reproduction and survival in different benthic organisms

Página do item simplificado
dc.contributor.authorMorais, Lucas Gonçalves [UNESP]
dc.contributor.authorGusso-Choueri, Paloma Kachel [UNESP]
dc.contributor.authorAbreu, Fiamma Eugênia Lemos
dc.contributor.authorCastro, Ítalo Braga
dc.contributor.authorAbessa, Denis Moledo [UNESP]
dc.contributor.authorChoueri, Rodrigo Brasil
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Santa Cecília
dc.contributor.institutionUniversidade Federal do Rio Grande (FURG)
dc.date.accessioned2023-07-29T13:42:20Z
dc.date.available2023-07-29T13:42:20Z
dc.date.issued2023-05-10
dc.description.abstractChlorothalonil is an organochlorine compound that has long been used in agriculture. In recent years, this compound has been used as an antifouling booster biocide and its presence has been reported in marine coastal environments, especially in navigational areas. Although sediment can be a sink for chlorothalonil due to high affinity to fine particulate matter, toxicity studies with non-target marine and/or estuarine organisms is focused on waterborne exposure only. This study aimed to determine sediment-borne ecotoxicological effects of chlorothalonil on different benthic organisms of the Latin American biota using a integrative multilevel approach. Marine/estuarine organisms were exposed to sediments spiked with chlorothalonil (from 0 to 10.0 μg g−1) and effects at sub-individual (biochemical biomarkers in Anomalocardia flexuosa), individual (lethal effects to Tiburonella viscana and Artemia salina) and subpopulation levels (Nitokra sp. reproduction) were assessed. Increasing chlorothalonil concentrations in sediment caused increasing ecotoxicological effects in different levels of biological organisation, from biochemical to subpopulation levels. The highest exposure concentrations showed increased biomarkers of effects (lipid peroxidation and DNA damage in gills and/or digestive gland of A. flexuosa), lower fecundity and lower survival of the test organisms. GPx activity associated with LPO levels in the digestive gland suggested a response to the oxidant challenge provided by the biocide. At the lowest concentration (0.001 μg g−1), chlorothalonil detoxification mechanisms and defense against its oxidising action, involving GSH and glutathione-dependent enzymes (GST and GPx) were induced. At intermediate concentrations, there was a tendency of decreasing GSH levels, probably due to conjugation with chlorothalonil, which also affected the activities of the glutathione-dependent enzymes. At the highest tested concentration (10.0 μg g−1), chlorothalonil may have restimulated GSH synthesis in the gills of A. flexuosa, although the prooxidant activity has induced effects. This study contributes to assessing the environmental risk of chlorothalonil in sediment for non-target marine and estuarine organisms.en
dc.description.affiliationDepartamento de Ciências do Mar Universidade Federal de São Paulo, Campus Baixada Santista, Rua Maria Máximo, 168, Ponta da Praia, Santos/SP
dc.description.affiliationCampus do Litoral Paulista Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp, Praça Infante Dom Henrique, s/n, SP
dc.description.affiliationLaboratório de Ecotoxicologia - Unisanta Universidade Santa Cecília, R. Oswaldo Cruz, 277, Boqueirão, SP
dc.description.affiliationInstituto de Oceanografia Universidade Federal do Rio Grande (FURG), Av. Italia s/n, km 8, Campus Carreiros, RS
dc.description.affiliationUnespCampus do Litoral Paulista Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp, Praça Infante Dom Henrique, s/n, SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFinanciadora de Estudos e Projetos
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFinanciadora de Estudos e Projetos: 1111/13
dc.description.sponsorshipIdFAPESP: 2020/03004-0
dc.description.sponsorshipIdCNPq: 301766/2019-3
dc.description.sponsorshipIdCNPq: 304398/2021-7
dc.description.sponsorshipIdCNPq: 308533/2018-6),
dc.description.sponsorshipIdCNPq: 456372/2013-0
dc.identifierhttp://dx.doi.org/10.1016/j.scitotenv.2023.162215
dc.identifier.citationScience of the Total Environment, v. 872.
dc.identifier.doi10.1016/j.scitotenv.2023.162215
dc.identifier.issn1879-1026
dc.identifier.issn0048-9697
dc.identifier.scopus2-s2.0-85148326104
dc.identifier.urihttp://hdl.handle.net/11449/248377
dc.language.isoeng
dc.relation.ispartofScience of the Total Environment
dc.sourceScopus
dc.subjectAntifouling
dc.subjectBiocide
dc.subjectEcotoxicology
dc.subjectGenotoxicity
dc.subjectOxidative stress
dc.subjectPollution
dc.titleMultilevel assessment of chlorothalonil sediment toxicity to Latin American estuarine biota: Effects on biomarkers, reproduction and survival in different benthic organismsen
dc.typeArtigo

Arquivos

Coleções

Artigos - Ciências Biológicas - São Vicente