Development of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeation

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dc.contributor.authorIsaac, Vera Lucia Borges [UNESP]
dc.contributor.authorChiari, Bruna G. [UNESP]
dc.contributor.authorMiglioli, Kamila [UNESP]
dc.contributor.authorMoreira, Raquel [UNESP]
dc.contributor.authorOliveira, José Ricardo Soares
dc.contributor.authorSalgado, Hérida [UNESP]
dc.contributor.authorRelkin, Perla
dc.contributor.authorCorrea, Marcos Antonio [UNESP]
dc.contributor.authorSalgado, Ana
dc.contributor.authorRibeiro, Helena M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLaboratório de Cosmetologia
dc.contributor.institutionAgroParis Tech - Massy
dc.contributor.institutionLisboan University
dc.date.accessioned2014-05-27T11:26:54Z
dc.date.available2014-05-27T11:26:54Z
dc.date.issued2012-08-01
dc.description.abstractFlavonoids have been widely incorporated into cosmetic and dermatological formulations, affording benefits such as antioxidant action, improved skin tone and fewer lines and wrinkles. Brazil has a huge biodiversity, with one of the richest flora in the world, and existing studies justify the quest for greater research efforts in this area. The cajazeira (Spondias lutea L.), a plant of the Anacardiaceae family from tropical America, is widely disseminated in Brazil. This plant was chosen because of the presence of flavonoids that exhibit antioxidant activity. The purpose of this research was to develop a stable topical formulation containing Spondias lutea extract with the aim of preventing skin diseases caused by UV radiation. Hydro ethanolic extract of Spondias lutea fruit was prepared and assayed for its the flavonoids content. The antioxidant activity was estimated by DPPH and superoxide assay. The physicochemical stability and skin permeation of the cream containing 8% (w/w) of extract were assessed. The results showed that the S. lutea extract possessed antioxidant activity, and that it is possible to obtain a stable cosmetic containing the extract, which is able to penetrate the skin. Thus, it is possible to use this extract to produce an anti-aging cosmetic.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas UNESP Univ Estadual Paulista, Araraquara
dc.description.affiliationDepartamento de Fármacos e Medicamentos Laboratório de Cosmetologia, LaCos
dc.description.affiliationAgroParis Tech - Massy
dc.description.affiliationiMed (Research Institute for Medicines and Pharmaceutical Sciences) Lisboan University, Lisboa
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas UNESP Univ Estadual Paulista, Araraquara
dc.format.extent174-179
dc.identifierhttp://dx.doi.org/10.7324/JAPS.2012.2830
dc.identifier.citationJournal of Applied Pharmaceutical Science, v. 2, n. 8, p. 174-179, 2012.
dc.identifier.doi10.7324/JAPS.2012.2830
dc.identifier.file2-s2.0-84876132775.pdf
dc.identifier.issn2231-3354
dc.identifier.lattes4842462513285606
dc.identifier.lattes3316011688829943
dc.identifier.scopus2-s2.0-84876132775
dc.identifier.urihttp://hdl.handle.net/11449/73472
dc.language.isoeng
dc.relation.ispartofJournal of Applied Pharmaceutical Science
dc.relation.ispartofsjr0,244
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntioxidant
dc.subjectCutaneous permeation
dc.subjectEmulsion
dc.subjectQuercetin
dc.subjectRutin
dc.subjectSpondias lutea
dc.titleDevelopment of a topical formulation containing S. Lutea extract: Stability, in vitro studies and cutaneous permeationen
dc.typeArtigo
dcterms.licensehttp://www.japsonline.com/about-japs.php
unesp.author.lattes4842462513285606
unesp.author.lattes3316011688829943
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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