Nanotechnology-based Drug Delivery Systems for Dermatomycosis Treatment

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dc.contributor.authorRibeiro de Souza, Ana Luiza [UNESP]
dc.contributor.authorKiill, Charlene Priscila [UNESP]
dc.contributor.authordos Santos, Fernanda Kolenyak [UNESP]
dc.contributor.authorda Luz, Gabriela Marielli [UNESP]
dc.contributor.authorRocha e Silva, Hilris [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorGremião, Maria Palmira Daflon [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:45Z
dc.date.available2014-05-20T13:24:45Z
dc.date.issued2012-09-01
dc.description.abstractDermatomycosis are fungal infections that involve the stratum corneum of the skin and the nails, hair, and surfaces of mucous membranes. Mycological infections represent important public health disorders, and their incidence has increased in recent years. This increase may result from a number of causes, such as an increase in the susceptible population, including the elderly and immunodeficient, and social and cultural exchanges associated with sports and the use of swimming pools. In immunodeficient individuals, the lesions associated with dermatomycosis are more intense, and what are initially superficial lesions can result in disseminated and fatal forms. The primary reasons for this include antifungal resistance, toxicity, lack of rapid and specific diagnoses and the poor penetration of drugs. The currently available antifungal agents for the treatment of dermatomycosis include azole and the allylamine group of drugs. The problems related to dermatomycosis therapy are the low residence times of the dosage forms in the site of action, side effects and variable drug permeability. Thus, novel topical drug delivery systems for antifungal therapy have been developed, including liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, silver nanoparticles, microemulsion and liquid crystals. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for dermatomycosis treatment.en
dc.description.affiliationUniv Estadual Paulista, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent512-519
dc.identifierhttp://dx.doi.org/10.2174/157341312801784311
dc.identifier.citationCurrent Nanoscience. Sharjah: Bentham Science Publ Ltd, v. 8, n. 4, p. 512-519, 2012.
dc.identifier.doi10.2174/157341312801784311
dc.identifier.issn1573-4137
dc.identifier.lattes9129780536724256
dc.identifier.urihttp://hdl.handle.net/11449/7769
dc.identifier.wosWOS:000310387500006
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Nanoscience
dc.relation.ispartofjcr1.306
dc.relation.ispartofsjr0,292
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectDermatomycosisen
dc.subjectdrug delivery systemsen
dc.subjectnanotechnologyen
dc.titleNanotechnology-based Drug Delivery Systems for Dermatomycosis Treatmenten
dc.typeArtigo
dcterms.licensehttp://www.benthamscience.com/permission.php
dcterms.rightsHolderBentham Science Publ Ltd
unesp.author.lattes9129780536724256
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas