Inflammatory reaction to the human bot-fly, Dermatobia hominis, in infested and reinfested mice

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dc.contributor.authorLello, E.
dc.contributor.authorde Rosis, AMB
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:51:25Z
dc.date.available2014-05-20T13:51:25Z
dc.date.issued2003-03-01
dc.description.abstractTwo groups of mice were infested with first stage larvae of the human bot-fly, Dermatobia hominis (Linnaeus Jr) (Diptera: Oestridae). In the first group, skin biopsies were carried out 1, 3, 5, 7, 10 and 18 days after infestation. The second group was also infested but had all the larvae removed 5 days after infestation. The mice in the latter group were reinfested 4 weeks later and skin biopsies were carried out 1, 3, 5, 7, 10 and 18 days after reinfestation. In the first group, an inflammatory reaction began slowly, the neutrophils being the main inflammatory cells, eosinophils being scarce. The reaction progressed with time, developing a necrotic halo around the larvae containing inflammatory cells surrounded by fibroblasts. The inflammation invaded the adjacent tissue. In the second group, the inflammatory reaction was intense on the day immediately after reinfestation, the pattern being changed by the presence of a large number of eosinophils. Activated fibroblasts surrounding the necrotic area around the larvae appeared 3 days after reinfestation in the second group and 7 days after infestation in the first group. The results demonstrated that the previous contact with the antigens elicited the early arrival of eosinophils, probably through the chemotactic factors liberated by mast cells in the anaphylactic reaction.en
dc.description.affiliationUniv Estadual Paulista, Dept Morfol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Ciências Biol, Fac Ciências, Bauru, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Morfol, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Ciências Biol, Fac Ciências, Bauru, SP, Brazil
dc.format.extent55-60
dc.identifierhttp://dx.doi.org/10.1046/j.1365-2915.2003.00407.x
dc.identifier.citationMedical and Veterinary Entomology. Oxford: Blackwell Publishing Ltd, v. 17, n. 1, p. 55-60, 2003.
dc.identifier.doi10.1046/j.1365-2915.2003.00407.x
dc.identifier.fileWOS000182117700008.pdf
dc.identifier.issn0269-283X
dc.identifier.lattes0711431566503022
dc.identifier.urihttp://hdl.handle.net/11449/18380
dc.identifier.wosWOS:000182117700008
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofMedical and Veterinary Entomology
dc.relation.ispartofjcr1.688
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectDermatobia hominispt
dc.subjecteosinophilspt
dc.subjectinflammationpt
dc.subjectmicept
dc.subjectneutrophilspt
dc.titleInflammatory reaction to the human bot-fly, Dermatobia hominis, in infested and reinfested miceen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentCiências Biológicas - FCpt

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Artigos - Morfologia - IBB
Bauru - FC - Faculdade de Ciências