Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction

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dc.contributor.authorGonçalves, Andrea F. [UNESP]
dc.contributor.authorPolegato, Bertha F. [UNESP]
dc.contributor.authorFernandes, Ana Angélica [UNESP]
dc.contributor.authorIshikawa, Larissa Lumi [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorBazan, Silméia G. Z. [UNESP]
dc.contributor.authorMinicucci, Marcos F. [UNESP]
dc.contributor.authorAzevedo, Paula S. [UNESP]
dc.contributor.authorIkoma, Maura R.
dc.contributor.authorPenitenti, Marcimara
dc.contributor.authorChiuso-Minicucci, Fernanda [UNESP]
dc.contributor.authorR Paiva, Sergio A. [UNESP]
dc.contributor.authorZornoff, Leonardo A. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAmaral Carvalho Fundation
dc.date.accessioned2019-10-06T15:59:20Z
dc.date.available2019-10-06T15:59:20Z
dc.date.issued2018-10-01
dc.description.abstractBackground/Aims: The objective of our study was to evaluate the effects of zinc supplementation on cardiac remodeling following acute myocardial infarction in rats. Methods: Animals were subdivided into 4 groups and observed for 3 months: 1) Sham Control; 2) Sham Zinc: Sham animals receiving zinc supplementation; 3) Infarction Control; 4) Infarction Zinc. After the followup period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, changes related to collagen, oxidative stress, and inflammation, assessed by echocardiogram, isolated heart study, western blot, flow cytometer, morphometry, and spectrophotometry. Results: Infarction induced a significant worsening of the functional variables. On the other hand, zinc attenuated both systolic and diastolic cardiac dysfunction induced by infarction. Considering the infarct size, there was no difference between the groups. Catalase and superoxide dismutase decreased in infarcted animals, and zinc increased its activity. We found higher expression of collagens I and III in infarcted animals, but there was no effect of zinc supplementation. Likewise, infarcted animals had higher levels of IL-10, but without zinc interference. Nrf-2 values were not different among the groups. Infarction increased the amount of Treg cells in the spleen as well as the amount of total lymphocytes. Zinc increased the amount of CD4+ in infarcted animals, but we did not observe effects in relation to Treg cells. Conclusion: zinc attenuates cardiac remodeling after infarction in rats; this effect is associated with modulation of antioxidant enzymes, but without the involvement of collagens I and III, Nrf-2, IL-10, and Treg cells.en
dc.description.affiliationSão Paulo State University (Unesp) Botucatu Medical School Internal Medicine Department
dc.description.affiliationSão Paulo State University (Unesp) Institute of Biosciences of Botucatu Chemistry and Biochemistry Department
dc.description.affiliationSão Paulo State University (Unesp) Institute of Biosciences of Botucatu Microbiology and Immunology Department
dc.description.affiliationFlow Citometry Laboratory Amaral Carvalho Fundation
dc.description.affiliationUnespSão Paulo State University (Unesp) Botucatu Medical School Internal Medicine Department
dc.description.affiliationUnespSão Paulo State University (Unesp) Institute of Biosciences of Botucatu Chemistry and Biochemistry Department
dc.description.affiliationUnespSão Paulo State University (Unesp) Institute of Biosciences of Botucatu Microbiology and Immunology Department
dc.format.extent363-377
dc.identifierhttp://dx.doi.org/10.1159/000494011
dc.identifier.citationCellular Physiology and Biochemistry, v. 50, n. 1, p. 363-377, 2018.
dc.identifier.doi10.1159/000494011
dc.identifier.issn1421-9778
dc.identifier.issn1015-8987
dc.identifier.scopus2-s2.0-85054488500
dc.identifier.urihttp://hdl.handle.net/11449/188165
dc.language.isoeng
dc.relation.ispartofCellular Physiology and Biochemistry
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectChronic remodeling
dc.subjectCoronary occlusion
dc.subjectFunction
dc.subjectHypertrophy
dc.subjectTreg cells
dc.subjectZinc
dc.titleZinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarctionen
dc.typeArtigo
unesp.author.lattes0077247086732148[3]
unesp.author.lattes4563764623232492[2]
unesp.author.orcid0000-0002-2875-9532[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

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Botucatu - FMB - Faculdade de Medicina
Artigos - Microbiologia e Imunologia - IBB
Artigos - Química e Bioquímica - IBB