Role of the antioxidant pathway in the healing of peptic ulcers induced by ischemia–reperfusion in male and female rats treated with Eugenia punicifolia

dc.contributor.authorLucena Périco, Larissa [UNESP]
dc.contributor.authorde Cássia dos Santos, Raquel
dc.contributor.authorPeixoto Rodrigues, Vinícius [UNESP]
dc.contributor.authorVasti Alfieri Nunes, Vânia [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorMachado da Rocha, Lúcia Regina [UNESP]
dc.contributor.authordos Santos, Catarina [UNESP]
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Calgary
dc.contributor.institutionSão Francisco University
dc.date.accessioned2023-03-01T23:41:28Z
dc.date.available2023-03-01T23:41:28Z
dc.date.issued2022-08-01
dc.description.abstractIschaemia and reperfusion (I/R)-induced gastrointestinal disorders are caused by free radicals, resulting in organ damage and functional disarrangement. This study aimed to investigate the healing effects of hydroalcoholic extracts from the leaves of Eugenia punicifolia (Kunth) DC. (HEEP) in male and female Wistar rats with I/R-induced peptic injuries, and the role of antioxidants in improving this response. After I/R-induced gastric and duodenal injuries, male and female [intact (INT) and ovariectomized (OVZ)] rats were orally treated with HEEP for 6 days. Biochemical analysis was used to determine the catalase (CAT), superoxide dismutase (SOD), and myeloperoxidase (MPO) activities, as well as malondialdehyde and reduced glutathione levels, to measure the gastric and duodenal healing process. Six days of HEEP treatment significantly decreased the I/R-induced gastric [male (73.68%), INT (52.83%), and OVZ (43.13%)] and duodenal damage [male (57.03%), INT (56.04%), and OVZ (54.83%)] in all groups. In OVZ rats, the healing effect of HEEP occurred because of the increased activity of SOD (2x) and CAT (1.16x) in the gastric mucosa. In the duodenal mucosa of INT rats, the extract reduced MPO (20.83%) activity. The 6-day HEEP treatment improved the healing of I/R-induced peptic ulcer injury, with the system acting differently in males and females. The antioxidant system is an important component of the HEEP activity during post-I/R mucosal recovery. This result revealed the importance of antioxidant compounds in minimizing the severity of I/R-related events.en
dc.description.affiliationDepartment of Structural and Functional Biology (Physiology) Biosciences Institute UNESP-São Paulo State University, São Paulo
dc.description.affiliationSnyder Institute for Chronic Diseases Cumming School of Medicine University of Calgary, 3330 Hospital Drive NW
dc.description.affiliationLaboratory of Pharmacology and Molecular Biology São Francisco University, CEP 12916-900, São Paulo
dc.description.affiliationBiosciences Institute UNESP−São Paulo State University, São Paulo
dc.description.affiliationDepartment of Biological Science Faculty of Sciences and Languages UNESP−São Paulo State University, São Paulo
dc.description.affiliationUnespDepartment of Structural and Functional Biology (Physiology) Biosciences Institute UNESP-São Paulo State University, São Paulo
dc.description.affiliationUnespBiosciences Institute UNESP−São Paulo State University, São Paulo
dc.description.affiliationUnespDepartment of Biological Science Faculty of Sciences and Languages UNESP−São Paulo State University, São Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2009/52237-90
dc.description.sponsorshipIdFAPESP: 2015/14979-3
dc.description.sponsorshipIdFAPESP: 2017/15610-0
dc.description.sponsorshipIdCNPq: 305570/2012-9
dc.description.sponsorshipIdCNPq: 306209/2016-0
dc.description.sponsorshipIdCAPES: 88882.183585/2018-01
dc.format.extent1383-1394
dc.identifierhttp://dx.doi.org/10.1007/s10787-022-00946-8
dc.identifier.citationInflammopharmacology, v. 30, n. 4, p. 1383-1394, 2022.
dc.identifier.doi10.1007/s10787-022-00946-8
dc.identifier.issn1568-5608
dc.identifier.issn0925-4692
dc.identifier.scopus2-s2.0-85128710947
dc.identifier.urihttp://hdl.handle.net/11449/241766
dc.language.isoeng
dc.relation.ispartofInflammopharmacology
dc.sourceScopus
dc.subjectAntioxidant
dc.subjectEugenia punicifolia
dc.subjectHealing effect
dc.subjectIschaemia–reperfusion
dc.subjectPeptic ulcers
dc.titleRole of the antioxidant pathway in the healing of peptic ulcers induced by ischemia–reperfusion in male and female rats treated with Eugenia punicifoliaen
dc.typeArtigo
unesp.author.orcid0000-0002-0888-9911[1]

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