Influence of moderate physical training on the GH/IGF-1 axis in diabetic rats

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dc.contributor.authorGomes, R. J.
dc.contributor.authorCaetano, F. H.
dc.contributor.authorMello, M. A. R.
dc.contributor.authorLuciano, E.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:54:31Z
dc.date.available2014-05-20T13:54:31Z
dc.date.issued2006-01-01
dc.description.abstractThe influence of moderate physical training on serum growth hormone (GH), insulin-like growth factor -1 (IGF-1) and binding protein ( IGFBP-3) in experimental diabetic rats was investigated. Male Wistar rats were divided into 4 groups, sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Experimental diabetes was induced of Alloxan (35mg/b.w.) the training program consisted by swimming 5 days/week, 1 h/day, supporting a load of 2.5% b.w., during 6 weeks. Then, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, GH, IGF-1 and IGFBP-3. Samples of liver were used to evaluate glycogen, protein and DNA contents. The results were analyzed by ANOVA, and Bonferroni test and the significance level was set at 2.5%. Diabetes decreased serum GH, IGF-1, IGFBP-3 and liver glycogen stores in SD group. Physical training promoted increase in serum IGF-1 in both TC and TD groups (SC=82 +/- 15; TC= 1 03 +/- 13; SD=77 +/- 16; TD= 112 +/- 29 ng/ml) and liver glycogen store in TD group when compared to SD (SC=5.2 +/- 1.2; TC= 6.2 +/- 1; SD=2 +/- 0.5; TD=5 +/- 1.8 mg/100mg). Therefore, physical training contributes to the increase in liver glycogen content and to rise of insulin-like growth factor level in diabetic rats. It was concluded that moderate physical training promotes important adaptations related to GH-IGF-1 axis in diabetic organisms.en
dc.description.affiliationState Univ São Paulo, UNESP, Dept Educ Phys, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationState Univ São Paulo, UNESP, Dept Biol, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespState Univ São Paulo, UNESP, Dept Educ Phys, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespState Univ São Paulo, UNESP, Dept Biol, BR-13506900 Rio Claro, SP, Brazil
dc.format.extent291-301
dc.identifierhttp://biolsport.com/abstracted.php?level=5&ICID=890842
dc.identifier.citationBiology of Sport. Warsaw 45: Inst Sport, v. 23, n. 3, p. 291-301, 2006.
dc.identifier.fileWOS000241394600007.pdf
dc.identifier.issn0860-021X
dc.identifier.lattes4396826019535898
dc.identifier.lattes2933779830637191
dc.identifier.urihttp://hdl.handle.net/11449/19499
dc.identifier.wosWOS:000241394600007
dc.language.isoeng
dc.publisherInst Sport
dc.relation.ispartofBiology of Sport
dc.relation.ispartofjcr1.729
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectDiabetes Mellituspt
dc.subjectgrowth hormonept
dc.subjectinsulin-like growth factor (IGF-1)pt
dc.subjectbinding protein (IGFBP-3)pt
dc.subjectphysical trainingpt
dc.titleInfluence of moderate physical training on the GH/IGF-1 axis in diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://biolsport.com/page.php?IDpage=1043&p=4
dcterms.rightsHolderInst Sport
unesp.author.lattes4396826019535898
unesp.author.lattes2933779830637191
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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