The plasmidome of multidrug-resistant emergent Salmonella serovars isolated from poultry

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dc.contributor.authorGaletti, Renata
dc.contributor.authorCasarin Penha Filho, Rafael Antonio [UNESP]
dc.contributor.authorFerreira, Joseane Cristina
dc.contributor.authorVarani, Alessandro M. [UNESP]
dc.contributor.authorSazinas, Pavelas
dc.contributor.authorJelsbak, Lars
dc.contributor.authorCosta Darini, Ana Lucia
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTech Univ Denmark
dc.date.accessioned2021-06-25T11:55:37Z
dc.date.available2021-06-25T11:55:37Z
dc.date.issued2021-04-01
dc.description.abstractThe rapid emergence of resistant bacteria is occurring worldwide. The understanding of the dissemination of antimicrobial resistance using high-throughput sequencing and bioinformatics approaches is providing valuable insights into the genetic basis of the horizontal gene transfer and the emergence of the antibiotic resistance threat. This ultimately can offer vital clues to the development of coordinated efforts to implement new policies to continue fighting against bacterial infections. The poultry microbiota is characterized as a potential reservoir of resistance genes, mostly derived from the Enterobacteriaceae which have become increasingly important in human and animal infections. In this work, complete genome sequences were achieved for four multidrugresistant Salmonella spp. isolated from poultry from different farms in Brazil. We identified highly similar IncHI2-ST2 megaplasmids (larger than 275.000 bp) in all Salmonella isolates studied. These megaplasmids carry a resistome comprised of eleven different resistance genes (aac(6?)-Iaa, aadA1b, aph(4)-Ia, aph(6)-Id, aph(3?)-Ib, aph(3?)-Ia, aac(3)-Iva, sul1, tetA, tetB and dfrA1b) and four heavy metal tolerance operons (telluride, mercury, silver and copper). In conclusion, the multidrug-resistant plasmids identified in S. enterica serovar Schwarzengrund and Newport isolated from poultry show a variety of antibiotic resistance and heavy metal tolerance genes, providing advantages for the bacteria to survive under extremely unfavorable conditions.en
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Fammceut Ribeirao Preto, Ave Cafe S-N, BR-14040903 Ribeirao Preto, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, Brazil
dc.description.affiliationTech Univ Denmark, Lyngby, Denmark
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipDanish Council for Independent Research
dc.description.sponsorshipIdFAPESP: 2014/14494-8
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2015/11728-0
dc.description.sponsorshipIdFAPESP: 2017/26311-3
dc.description.sponsorshipIdDanish Council for Independent Research: 6108-00300A
dc.format.extent4
dc.identifierhttp://dx.doi.org/10.1016/j.meegid.2021.104716
dc.identifier.citationInfection Genetics And Evolution. Amsterdam: Elsevier, v. 89, 4 p., 2021.
dc.identifier.doi10.1016/j.meegid.2021.104716
dc.identifier.issn1567-1348
dc.identifier.urihttp://hdl.handle.net/11449/209302
dc.identifier.wosWOS:000636302900013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInfection Genetics And Evolution
dc.sourceWeb of Science
dc.subjectPlasmids
dc.subjectAntibiotic resistance
dc.subjectHeavy metal tolerance
dc.subjectPoultry
dc.titleThe plasmidome of multidrug-resistant emergent Salmonella serovars isolated from poultryen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-5759-9769[6]

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