Evaluation of osteoconduction of biphasic calcium phosphate ceramic in the calvaria of rats: Microscopic and histometric analysis

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dc.contributor.authorDe Oliveira Puttini, Igor [UNESP]
dc.contributor.authorPoli, Pier Paolo
dc.contributor.authorMaiorana, Carlo
dc.contributor.authorDe Vasconcelos, Igor Rodrigues
dc.contributor.authorSchmidt, Luis Eduardo
dc.contributor.authorColombo, Luara Teixeira [UNESP]
dc.contributor.authorHadad, Henrique [UNESP]
dc.contributor.authorDos Santos, Gabriel Mulinari [UNESP]
dc.contributor.authorDe Carvalho, Paulo Sergio Perri [UNESP]
dc.contributor.authorSouza, Francisley Ávila [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Milan
dc.contributor.institutionSão Leopoldo Mandic School of Dentistry and Research Center
dc.date.accessioned2019-10-06T16:34:20Z
dc.date.available2019-10-06T16:34:20Z
dc.date.issued2019-01-01
dc.description.abstract(1) Background: Evaluate the osteoconduction capability of a biphasic calcium phosphate (BCP) ceramic composed of hydroxyapatite and β-tricalcium phosphate 60%/40% in a rat model. (2) Methods: In the calvarial bone of 54 adult male rats, 7-mm diameter critical size defects were performed. The animals were randomly allocated to three experimental groups according to the type of material: blood clot (BCG), blood clot covered with a bovine-derived collagen membrane (MBCG), and BCP ceramic covered with a bovine-derived collagen membrane (BCPG). In each group, 6 animals were euthanatized at post-operative days 7, 30, and 60 for histological and histometric analysis. (3) Results: The qualitative analysis revealed the persistence of the collagen membrane at seven days, with no relevant newly bone formation in all groups. At 30 days, centripetal bone formation was observed residual particles of the biomaterial surrounded by fibroblasts noted in the BCPG. At 60 days, while BCG and MBCG showed a partial maturation with the central part of the defect populated by a fibrous connective tissue, in the BCPG the critical area was entirely occupied by newly formed bone. In the intra groups analysis was noted a significant increase in new bone formation during the experimental period (p < 0.05). At 60 days, BCPG showed a higher percentage area of new bone formation (p < 0.05). (4) Conclusion: BCP promoted a new bone formation by osteoconduction and might be considered a valid alternative in bone regeneration procedures.en
dc.description.affiliationDepartment of Surgery and Integrated Clinic Araçatuba Dental of School São Paulo State University Júlio de Mesquita Filho-UNESP
dc.description.affiliationImplant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCSS Cà Granda Maggiore Policlinico Hospital University of Milan
dc.description.affiliationImplant Dentistry Post-Graduation Program São Leopoldo Mandic School of Dentistry and Research Center
dc.description.affiliationUnespDepartment of Surgery and Integrated Clinic Araçatuba Dental of School São Paulo State University Júlio de Mesquita Filho-UNESP
dc.identifierhttp://dx.doi.org/10.3390/jfb10010007
dc.identifier.citationJournal of Functional Biomaterials, v. 10, n. 1, 2019.
dc.identifier.doi10.3390/jfb10010007
dc.identifier.issn2079-4983
dc.identifier.scopus2-s2.0-85067098449
dc.identifier.urihttp://hdl.handle.net/11449/189237
dc.language.isoeng
dc.relation.ispartofJournal of Functional Biomaterials
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiphasic calcium phosphate
dc.subjectBone regeneration
dc.subjectBone substitute
dc.subjectCeramics
dc.titleEvaluation of osteoconduction of biphasic calcium phosphate ceramic in the calvaria of rats: Microscopic and histometric analysisen
dc.typeArtigo

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Artigos - Cirurgia e Clínica Integrada - FOA