Avermectin toxicity in bovines less than thirty days old

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dc.contributor.authorde Castro Rodrigues, Daniel
dc.contributor.authorBuzullini, Carolina [UNESP]
dc.contributor.authorPereira, Tiago Arantes
dc.contributor.authorCurz, Breno Cayeiro [UNESP]
dc.contributor.authorGomes, Lucas Vinicius Costa [UNESP]
dc.contributor.authorSoares, Vando Edésio
dc.contributor.authorBastos, Thiago Souza Azeredo
dc.contributor.authorCouto, Luiz Fellipe Monteiro
dc.contributor.authorLopes, Welber Daniel Zanetti [UNESP]
dc.contributor.authorde Oliveira, Gilson Pereira [UNESP]
dc.contributor.authorCosta, Alvimar José da [UNESP]
dc.contributor.institutionMSD Animal Health
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Brasil
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2018-12-11T17:19:34Z
dc.date.available2018-12-11T17:19:34Z
dc.date.issued2018-06-01
dc.description.abstractThe present study was designed to evaluate possible adverse effects of different dosages of avermectins (abamectin and a combination of ivermectin + abamectin) administered subcutaneously in calves less than one month of age. Clinical as well as biochemical parameters of blood and cerebrospinal fluid (CSF) were evaluated for animals subjected to various treatments. Thirty-five calves were divided into seven groups of five animals each: T01 (control), T02 (abamectin 200 μg/kg), T03 (abamectin 400 μg/kg), T04 (abamectin 600 μg/kg), T05 (ivermectin 450 μg/kg + abamectin 250 μg/kg), T06 (ivermectin 900 μg/kg + abamectin 500 μg/kg) and T07 (ivermectin 1350 μg/kg + abamectin 750 μg/kg). Cerebrospinal fluid and blood samples were collected on day zero (treatment day) and on days 1, 7 and 14 following treatment. The biochemical parameters measured in blood samples were total protein and the AST, GGT and alkaline phosphatase enzymes. In CSF samples, color, aspects, pH, density, cellularity, total proteins, glucose and the CK, ALT and LDH enzymes were evaluated. No neurological toxicity or biochemical changes in the CSF or blood that could be correlated to administration of tested products were observed in this study. Though it is well known that abamectin may lead to intoxication in bovines less than four months of age, based on data from the present study, no adverse clinical effects to the CSF or blood were observed in calves <30 days old that had received up to 600 μg/kg abamectin formulations and up to 1350 μg/kg ivermectin +750 μg/kg abamectin associations. It is possible that the level and activity of the multiple drug resistance gene (MDR1 - ABCB1) present in the calves may have influenced the results obtained in this study. Future studies should be carried out.en
dc.description.affiliationMSD Animal Health
dc.description.affiliationCPPAR - Animal Health Research Center Faculdade de Ciências Agrárias e Veterinárias UNESP, Campus de Jaboticabal, Via de acesso Prof. Paulo Donatto Castellane, s/n°
dc.description.affiliationUniversidade Brasil Campus de Descalvado
dc.description.affiliationInstituto de Patologia Tropical e Saúde Pública Universidade Federal de Goiás (IPTSP/UFG)
dc.description.affiliationUnespCPPAR - Animal Health Research Center Faculdade de Ciências Agrárias e Veterinárias UNESP, Campus de Jaboticabal, Via de acesso Prof. Paulo Donatto Castellane, s/n°
dc.format.extent403-412
dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.2018.04.003
dc.identifier.citationResearch in Veterinary Science, v. 118, p. 403-412.
dc.identifier.doi10.1016/j.rvsc.2018.04.003
dc.identifier.file2-s2.0-85045688437.pdf
dc.identifier.issn1532-2661
dc.identifier.issn0034-5288
dc.identifier.scopus2-s2.0-85045688437
dc.identifier.urihttp://hdl.handle.net/11449/176201
dc.language.isoeng
dc.relation.ispartofResearch in Veterinary Science
dc.relation.ispartofsjr0,593
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAbamectin
dc.subjectCalves
dc.subjectCentral nervous system
dc.subjectIvermectin + abamectin
dc.titleAvermectin toxicity in bovines less than thirty days olden
dc.typeArtigo
unesp.author.lattes4587241487071929[11]

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