The Influence of Pregnancy on Female Prostate Morphophysiology in Gerbils (Meriones unguiculatus)

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dc.contributor.authorGomes, Lorranny de Jesus
dc.contributor.authorRodrigues, Giovanna Amaral
dc.contributor.authorMalmann Medeiros, Barbara Costa
dc.contributor.authorManso, Luana Araujo
dc.contributor.authorRamos, Jordana Gomes
dc.contributor.authorAzevedo Brito, Pedro Vale de
dc.contributor.authorTaboga, Sebastiao Roberto [UNESP]
dc.contributor.authorCarvalho, Hernandes Faustino de
dc.contributor.authorAlcantara dos Santos, Fernanda Cristina
dc.contributor.authorBiancardi, Manoel Francisco
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2021-06-25T12:38:01Z
dc.date.available2021-06-25T12:38:01Z
dc.date.issued2021-02-16
dc.description.abstractMorphophysiological changes of the female prostate during pregnancy are still little known. Considering that this gland is highly influenced by steroid hormones, the aim of this study was to evaluate the impact of the pregnancy on female prostate morphophysiology in gerbils. Pregnant females were timed, and the prostates were analyzed at pregnancy days 6 (P6), 12 (P12), 18 (P18), and 24 (P24). Virgin females were used as the control group (C). We observed a profound change in the hormonal profile during gestation, which was marked by a high oscillation of the progesterone (P4) hormone. P4 serum levels increased, peaking at the middle of gestation, and decreased to the end of the pregnancy. The morphology of the gland in pregnant females also changed, being marked by an increase of acini lumen, and a decrease in stroma. Indeed, the acinar changes during pregnancy were followed by a significant reduction of the epithelial height, besides a change of the smooth muscle cells' morphology that became more relaxed. The number of progesterone receptor (PR) and androgen receptor (AR)-positives cells decreased with the increase of progesterone serum levels, showing an inverse relationship. Finally, we observed a reduction of epithelial proliferation and a significant increase of gland PAS-positive secretion at the end of pregnancy. Altogether, these results showed, for the first time, that the female prostate morphophysioloy is profoundly influenced by the gestational period, suggesting that the fluctuation of the P4 serum levels is the main factor influencing the gland during this period.en
dc.description.affiliationUniv Fed Goias, Dept Histol Embryol & Cell Biol, Microscopy Lab Appl Reprod, Av Esperanca S-N,Campus Samambaia, BR-74690900 Goiania, Go, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Struct & Funct Biol, Campinas, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipFundacao de Amparo a Pequisa do Estado de Goias -Brazil (FAPEG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFundacao de Amparo a Pequisa do Estado de Goias -Brazil (FAPEG): 08/2018
dc.description.sponsorshipIdCNPq: 422302/2018-0
dc.description.sponsorshipIdCAPES: 001
dc.format.extent12
dc.identifierhttp://dx.doi.org/10.1007/s43032-021-00475-9
dc.identifier.citationReproductive Sciences. Heidelberg: Springer Heidelberg, 12 p., 2021.
dc.identifier.doi10.1007/s43032-021-00475-9
dc.identifier.issn1933-7191
dc.identifier.urihttp://hdl.handle.net/11449/210045
dc.identifier.wosWOS:000618606300001
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofReproductive Sciences
dc.sourceWeb of Science
dc.subjectFemale prostate
dc.subjectProgesterone
dc.subjectGerbil
dc.subjectPregnancy
dc.titleThe Influence of Pregnancy on Female Prostate Morphophysiology in Gerbils (Meriones unguiculatus)en
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.orcid0000-0001-9995-3546[10]

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