Detection of cytokeratins in ghost cells of calcifying cystic odontogenic tumor indicates an altered keratinization and hair follicle differentiation for their development

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dc.contributor.authorKaminagakura, Estela
dc.contributor.authorDomingos, Patrícia Luciana Batista
dc.contributor.authorda Rosa, Marize Raquel Diniz
dc.contributor.authorLoyola, Adriano Mota
dc.contributor.authorCardoso, Sérgio Vitorino
dc.contributor.authorLopes, Maria Cândida de Almeida
dc.contributor.authorBonan, Paulo Rogério Ferreti
dc.contributor.authorde Faria, Paulo Rogério
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.date.accessioned2014-05-27T11:30:50Z
dc.date.available2014-05-27T11:30:50Z
dc.date.issued2013-10-10
dc.description.abstractCalcifying cystic odontogenic tumors (CCOTs) are benign cystic lesions of odontogenic origin characterized by an ameloblastoma-like epithelium and the presence of a group of cells named ghost cells. The pattern of cytokeratin (Ck) expression on these lesions remains unclear and needs to be clarified. To this end, the expression of Ck6, Ck13, Ck14, Ck18, and Ck19 in the epithelium lining of 7 cases of CCOTs was evaluated by immunohistochemistry. For this, the epithelium lining was divided into 3 distinct regions: basal layer, suprabasal layer, and the compartment composed of ghost cells. In this study, 6 cases (85.7%) were classified as type 1 and 1 (14.3%) as type 4. All cases were negative for Ck13 and Ck18, despite the epithelial layer, as well as in the ghost cells. Ck6 was only positive in the ghost cells. Positivity for Ck14 and Ck19 was found in the basal and suprabasal layers, including the ghost cells. The results showing positivity for Ck14 and Ck19 in all of the analyzed cases reinforce CCOT as being of odontogenic origin, and the restricted expression of Ck6 in the ghost cells may be indicative that these cells suffer an altered differentiation into hair follicles in CCOTs. © 2013 Elsevier Inc. All rights reserved.en
dc.identifierhttp://dx.doi.org/10.1016/j.anndiagpath.2013.07.002
dc.identifier.citationAnnals of Diagnostic Pathology.
dc.identifier.doi10.1016/j.anndiagpath.2013.07.002
dc.identifier.issn1092-9134
dc.identifier.issn1532-8198
dc.identifier.scopus2-s2.0-84885009102
dc.identifier.urihttp://hdl.handle.net/11449/76815
dc.identifier.wosWOS:000327578500010
dc.language.isoeng
dc.relation.ispartofAnnals of Diagnostic Pathology
dc.relation.ispartofjcr1.633
dc.relation.ispartofsjr0,642
dc.relation.ispartofsjr0,642
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCalcifying cystic odontogenic tumor
dc.subjectCytokeratins
dc.subjectImmunohistochemistry
dc.subjectOdontogenic
dc.subjectPathogenesis
dc.subjectTumors
dc.titleDetection of cytokeratins in ghost cells of calcifying cystic odontogenic tumor indicates an altered keratinization and hair follicle differentiation for their developmenten
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy

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