Nuclear morphometry in histological specimens of canine prostate cancer: Correlation with histological subtypes, Gleason score, methods of collection and survival time

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dc.contributor.authorDi Donato, Guido
dc.contributor.authorLaufer-Amorim, Renée [UNESP]
dc.contributor.authorPalmieri, Chiara
dc.contributor.institutionIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale”
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionThe University of Queensland
dc.date.accessioned2018-12-11T17:11:45Z
dc.date.available2018-12-11T17:11:45Z
dc.date.issued2017-10-01
dc.description.abstractTen normal prostates, 22 benign prostatic hyperplasia (BPH) and 29 prostate cancer (PC) were morphometrically analyzed with regard to mean nuclear area (MNA), mean nuclear perimeter (MNP), mean nuclear diameter (MND), coefficient of variation of the nuclear area (NACV), mean nuclear diameter maximum (MDx), mean nuclear diameter minimum (MDm), mean nuclear form ellipse (MNFe) and form factor (FF). The relationship between nuclear morphometric parameters and histological type, Gleason score, methods of sample collection, presence of metastases and survival time of canine PC were also investigated. Overall, nuclei from neoplastic cells were larger, with greater variation in nuclear size and shape compared to normal and hyperplastic cells. Significant differences were found between more (small acinar/ductal) and less (cribriform, solid) differentiated PCs with regard to FF (p < 0.05). MNA, MNP, MND, MDx, and MDm were significantly correlated with the Gleason score of PC (p < 0.05). MNA, MNP, MDx and MNFe may also have important prognostic implications in canine prostatic cancer since negatively correlated with the survival time. Biopsy specimens contained nuclei that were smaller and more irregular in comparison to those in prostatectomy and necropsy specimens and therefore factors associated with tissue sampling and processing may influence the overall morphometric evaluation. The results indicate that nuclear morphometric analysis in combination with Gleason score can help in canine prostate cancer grading, thus contributing to the establishment of a more precise prognosis and patient's management.en
dc.description.affiliationIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale”
dc.description.affiliationDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science – Univ. Estadual Paulista – UNESP
dc.description.affiliationSchool of Veterinary Science The University of Queensland, Gatton campus
dc.description.affiliationUnespDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science – Univ. Estadual Paulista – UNESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 306055/2011-2012
dc.description.sponsorshipIdCNPq: 443884/2014-2015
dc.format.extent212-217
dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.2017.05.007
dc.identifier.citationResearch in Veterinary Science, v. 114, p. 212-217.
dc.identifier.doi10.1016/j.rvsc.2017.05.007
dc.identifier.file2-s2.0-85019139044.pdf
dc.identifier.issn1532-2661
dc.identifier.issn0034-5288
dc.identifier.scopus2-s2.0-85019139044
dc.identifier.urihttp://hdl.handle.net/11449/174570
dc.language.isoeng
dc.relation.ispartofResearch in Veterinary Science
dc.relation.ispartofsjr0,593
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCancer
dc.subjectDog
dc.subjectNuclear morphometry
dc.subjectProstate
dc.titleNuclear morphometry in histological specimens of canine prostate cancer: Correlation with histological subtypes, Gleason score, methods of collection and survival timeen
dc.typeArtigo
unesp.author.orcid0000-0001-8606-5291[1]

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Artigos - Clínica Veterinária - FMVZ