Adjuvant therapies in the management of medication-related osteonecrosis of the jaws: Systematic review

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dc.contributor.authorde Souza Tolentino, Elen
dc.contributor.authorde Castro, Tamara F. [UNESP]
dc.contributor.authorMichellon, Felipe C.
dc.contributor.authorPassoni, Ana C. C.
dc.contributor.authorOrtega, Lorena J. A.
dc.contributor.authorIwaki, Lilian C. V.
dc.contributor.authorda Silva, Mariliani C.
dc.contributor.institutionState University of Maringá
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:47:35Z
dc.date.available2019-10-06T16:47:35Z
dc.date.issued2019-01-01
dc.description.abstractBackground: We investigated the efficacy of hyperbaric oxygen (HBO), low-intensity laser (LIL), and platelet-rich plasma (PRP) in the management of medication-related osteonecrosis of the jaws (MRONJ). Methods: A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data. Results: There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed. Conclusions: These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high-quality investigations on the subject.en
dc.description.affiliationDepartment of Dentistry State University of Maringá
dc.description.affiliationOral Oncology Center São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationUnespOral Oncology Center São Paulo State University (Unesp) School of Dentistry
dc.identifierhttp://dx.doi.org/10.1002/hed.25944
dc.identifier.citationHead and Neck.
dc.identifier.doi10.1002/hed.25944
dc.identifier.issn1097-0347
dc.identifier.issn1043-3074
dc.identifier.scopus2-s2.0-85072190335
dc.identifier.urihttp://hdl.handle.net/11449/189653
dc.language.isoeng
dc.relation.ispartofHead and Neck
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjecthyperbaric oxygen
dc.subjectlaser therapy
dc.subjectmedication-related osteonecrosis of the jaw
dc.subjectosteonecrosis
dc.subjectplatelet-rich plasma
dc.titleAdjuvant therapies in the management of medication-related osteonecrosis of the jaws: Systematic reviewen
dc.typeResenha
unesp.author.orcid0000-0002-0394-9647[2]

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